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ProteomicsAllosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism
BCL-xL promotes cell survival by binding BH3-only initiators through its hydrophobic groove. Combining resonance energy transfer assays and molecular dynamics simulations, we unravel that membrane anchoring of BCL-xL via its C-terminal tail selectively advantages binding to membrane-anchored PUMA in...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD066303 | Pride
Puma Tail anchors Bcl-xl Bax Tripletof 5600+ Bh3 mimetic Swath 
GenomicsPutting the STING back into BH3-mimetic drugs for TP53 mutant blood cancers
Putting the STING back into BH3-mimetic drugs for TP53 mutant blood cancers
PRJNA1086799 | ENA
ProteomicsMitochondrial E3 ubiquitin ligase MARCHF5 controls BAK function independently of BH3-only proteins
Intrinsic apoptosis is principally regulated by the BCL-2 family of proteins, but some non-BCL-2 proteins also serve as important regulators. To identify novel apoptosis regulators, we performed a genome-wide CRISPR-Cas9 library screen, and it identified the mitochondrial E3 ubiquitin ligase MARCHF5...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-25 | PXD030246 | Pride
Apoptosis  bak  bcl-2  marchf5/mitol  e3 ubiquitin ligase  mitochondria  bh3 mimetic 
TranscriptomicsPutting the STING back into BH3-mimetic drugs for TP53 mutant blood cancers
TP53-mutant blood cancers remain a major clinical challenge. BH3-mimetic drugs inhibit BCL-2 pro-survival proteins to promote cancer cell apoptosis. Despite acting downstream of TP53, functional TP53 is required for maximal cancer cell killing by BH3-mimetics through an unknown mechanism. Here, we r...
ORGANISM(S): Mus musculus 
2024-04-25 | GSE261373 | GEO
UnknownHypericin, a potential new BH3 mimetic
Not available
S-EPMC9577225 | biostudies-literature
UnknownDynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer.
Not available
S-EPMC8316436 | biostudies-literature
UnknownTargeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.
Not available
S-EPMC8520471 | biostudies-literature
UnknownAllosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism.
Not available
S-EPMC12660782 | biostudies-literature
UnknownDRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.
Not available
S-EPMC6637195 | biostudies-literature
TranscriptomicsMCL1 inhibitor induces apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma
Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignanices and contributes to leukemogenesis by inhibiting the apoptotic machinery of the cells. BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leuke...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10903 | biostudies-arrayexpress
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