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TranscriptomicsRNA Seq analysis of Mefs Isolated from STC1+/+ and STC1-/- mice
Evaluation of X-linked gene expression in MEFs isolated from STC1 wild type and knock out mice X chromosome inactivation (XCI) is initiated in cis by the Xist RNA, which coats the inactive X chromosome (Xi) from which it is produced. We performed a large-scale RNA interference screen to identify tr...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-47395 | biostudies-arrayexpress
ProteomicsTargeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype
The X chromosome inactivation (XCI) is induced by Xist long non-coding RNA and protein-coding genes. However, the small non-coding RNA function in XCI remains unidentified. Our genome-wide, loss-of-function CRISPR/Cas9 screen in female fibroblasts examines the role of microRNA (miRNAs) in XCI. A str...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD064749 | Pride
Lcms Mus mus Chirp-ms 
TranscriptomicsTRIM37 is a novel H2A ubiquitin ligase and a Breast Cancer Oncogene
The TRIM37 gene is mutatedin Mulbery nanism, a rare autosomal recessive disorder, and is in the 17q23 chromosomal region that is amplified in up to ~40% of breast cancers. Trim37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases, but the protein substrate(s) of Trim37 is unknown. Mo...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-48196 | biostudies-arrayexpress
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