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ProteomicsMapping the CCL8:P672 interface using HDX-MS
We use HDX-MS to characterise the binding interface between the tick evasin P672 and the chemokine CCL8, in order to assist in the development of peptides capable of mimicking P672 anti-inflammatory activity.
ORGANISM(S): Rhipicephalus pulchellus 
2020-05-29 | PXD019199 | Pride
Chemokine Inflammation Evasin Protein-protein interaction 
GenomicsUK10K RARE CHD
In the UK10K project we propose a series of complementary genetic approaches to find new low frequency/rare variants contributing to disease phenotypes. These will be based on obtaining the genome wide sequence of 4000 samples from the TwinsUK and ALSPAC cohorts (at 6x sequence coverage), and the ex...
EGAS00001000125 | EGA
ProteomicsEvasin RHIPU-P672 characterization
Characterization of glycosylation sites of evasin RHIPU-P672
ORGANISM(S): Rhipicephalus pulchellus 
2018-03-01 | PXD008025 | Pride
Glycosylation sites Rhipu-p672 
GenomicsFunctional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells
The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here we characterize AEBP2, a known PRC2 cofactor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, incl...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-83082 | biostudies-arrayexpress
GenomicsEGAS00001000317-sc-20140326 - samples
The exome sequencing is performed using Agilent SureSelect 50Mb exome v3 and Hiseq 75bp paired reads with an mean sequencing coverage target of 50X.
EGAD00001000799 | EGA
Genomicsuk10k_rare_chd_rel_2012_07_05-sc-20120727 - samples
UK10K_RARE_CHD REL-2012-07-05
EGAD00001000210 | EGA
Genomicsuk10k_rare_chd_rel_2012_01_13-sc-20120611 - samples
UK10K_RARE_CHD REL-2012-01-13
EGAD00001000178 | EGA
Genomicsuk10k_rare_chd_rel_2012_02_22-sc-20120613 - samples
UK10K_RARE_CHD REL-2012-02-22
EGAD00001000192 | EGA
Genomicsuk10k_rare_chd_rel_2013_04_20-sc-20130522 - samples
UK10K_RARE_CHD REL-2013-04-20
EGAD00001000413 | EGA
Genomicsuk10k_rare_chd_rel_2012_11_27-sc-20121218 - samples
UK10K_RARE_CHD REL-2012-11-27
EGAD00001000294 | EGA
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