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TranscriptomicsTranscription profiling by array of Rattus norvegicus cardiomyocytes to investigate the effects of PD184352 and BI-D1870 on changes in expression induced by endothelin-1
Cardiomyocytes were exposed to PD184352, BI-D1870 or endothelin-1 alone, or to endothelin-1 in the presence of each inhibitor
ORGANISM(S): Rattus norvegicus 
2013-01-16 | E-MEXP-3679 | biostudies-arrayexpress
ProteomicsPharmacokinetic analysis of a novel human EGFRvIII:CD3 bispecific antibody in plasma and whole blood using a high-resolution targeted mass spectroscopy approach
Bi-specific single change antibody fragments (bi-scFv) represent an emerging class of biotherapeutics. We recently developed a fully human bi-scFv (EGFRvIII:CD3 bi-scFv) with the goal of redirecting CD3-expressiong T cells to recognize and destroy malignant, EGFR-expressing glioma. In mice, we showe...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD012472 | panorama
MetabolomicsMulti-omics integration reveals Yu-Xue-Bi tablets attenuate rheumatoid arthritis via metabolic reprogramming-mediated Piezo1 suppression

As a systemic chronic inflammatory disease, Rheumatoid arthritis (RA) is characterized by progressive inflammation, bone and cartilage destruction, leading to significant disability, reduced lifespan, and increased mortality. The clinical use of conventional medications including nonsteroidal ant...

2026-01-24 | MTBLS13760 | MetaboLights
ProteomicsCross-linking mass spectrometry for protein structure analysis with homo-bifunctional cross-linkers
Cross-linking mass spectrometry for protein structure analysis with homo-bi-functional photo-activatable cross-linkers. Cross-linkers were applied to BSA, importin-alpha/beta, and dengue NS2b-NS3 protease protein complexes.
ORGANISM(S): Homo Sapiens (human) Cellular Organisms 
2026-01-05 | PXD067180 | JPOST Repository
TranscriptomicsExpression profiling of Candida albicans and Candida dubliniensis in reconstituted human oral epithelium 90 min p.i.
Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. albicans gene arrays were used for comparative analysis of global gene expressio...
ORGANISM(S): Candida dubliniensis 
2010-05-16 | E-GEOD-13345 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Candida albicans and Candida dubliniensis in reconstituted human oral epithelium 30 min p.i.
Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. albicans gene arrays were used for comparative analysis of global gene expressio...
ORGANISM(S): Candida albicans 
2010-05-16 | E-GEOD-13318 | biostudies-arrayexpress
ProteomicsTranslation of bi-directional transcripts generates peptides for the MHC-I pathway.
Antisense transcripts play an important role in generating regulatory non-coding RNAs but if these transcripts are also translated and for what purpose is yet poorly understood. Isolation of polysome fractions followed by RNA sequencing and mass spectrometry analysis of a six frame data-base reveale...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057573 | Pride
Human Mass spectrometry Polysomes Mhc-i pathway 
ProteomicsRelative Quantitative Analysis of Site-Specific N-Linked Glycosylation in Hyperglycosylated In-terferon-β via Mass Spectrometry
Glycosylation is a critical determinant of the efficacy, stability, and pharmacological behavior of therapeutic proteins. R27T, an engineered variant of interferon-β1a, contains two N-glycosylation sites (Asn25 and Asn80), increasing its structural complexity and analytical requirements. In this stu...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD077477 | Pride
Interferon beta  n-linked glycan  site-specific glycosylation  relative quantitative analysis  r27t 
TranscriptomicsDifferential gene expression profiles between myeloid-biased and lymphoid-biased hematopoietic stem cells.
Array analysis of My-bi and Ly-bi HSC identifies candidate molecules for myeloid-bias. Collectively the data show that HSC in adults are largely epigenetically fixed in differentiation and self-renewal behavior. A direct examination of the epigenetic mechanisms that imprint HSC is difficult. However...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-41702 | biostudies-arrayexpress
ProteomicsViral pIC-pocketing: RSV sequestration of eIF4F Initiation Complexes into bi-phasic biomolecular condensates
Orthopneumoviruses characteristically form membrane-less cytoplasmic inclusion bodies (IBs) wherein RNA replication and transcription occur. Herein, we report a strategy whereby the orthopneumoviruses sequester various components of the eiF4F Initiation Complex machinery into viral IBs to facilitate...
ORGANISM(S): Homo sapiens (Human) 
2024-02-02 | PXD041843 | Pride
Respiratory syncytial virus Eif4f complex Inclusion bodies 
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