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ProteomicsCHD8 Suppression Impacts on Histone H3 Lysine 36 Trimethylation and Alters RNA Alternative Splicing
Disruptive mutations in the chromodomain helicase DNA binding protein 8 (CHD8) have been recurrently associated with Autism Spectrum Disorders (ASD). Here we investigated how chromatin reacts to CHD8 suppression by analyzing a panel of histone modifications in induced pluripotent stem cell-derived n...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025739 | Pride
Autism spectrum disorder Chd8 Alternative splicing Chromatin H3k36me3 
ProteomicsSINEUP RNA rescues molecular phenotypes associated with CHD8 suppression in Autism Spectrum Disorder model systems
Loss-of-function mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are strongly associated with Autism Spectrum Disorders (ASD). Indeed, the reduction of CHD8 causes transcriptional, epigenetic and cellular phenotypic changes, correlated to disease that can be monitored in assessing n...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD056482 | Pride
Chd8  sineup  autism spectrum disorders (asd)  lncrna  neurodeveloment  zebrafish 
GenomicsCHD8M-BM- regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [ChIP-Seq]
Truncating mutations of CHD8, encoding a chromodomain helicase, and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates in neural pr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-61487 | biostudies-arrayexpress
TranscriptomicsCHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [RNA-Seq]
Truncating mutations of CHD8, encoding a chromodomain helicase, and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates in neural pr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-61491 | biostudies-arrayexpress
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