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ProteomicsCHD8 Suppression Impacts on Histone H3 Lysine 36 Trimethylation and Alters RNA Alternative Splicing
Disruptive mutations in the chromodomain helicase DNA binding protein 8 (CHD8) have been recurrently associated with Autism Spectrum Disorders (ASD). Here we investigated how chromatin reacts to CHD8 suppression by analyzing a panel of histone modifications in induced pluripotent stem cell-derived n...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD025739 | Pride
Autism spectrum disorder Chd8 Alternative splicing Chromatin H3k36me3 
GenomicsCHD8M-BM- regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [ChIP-Seq]
Truncating mutations of CHD8, encoding a chromodomain helicase, and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates in neural pr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-61487 | biostudies-arrayexpress
TranscriptomicsCHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors [RNA-Seq]
Truncating mutations of CHD8, encoding a chromodomain helicase, and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates in neural pr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-61491 | biostudies-arrayexpress
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