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ProteomicsFBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Dysregulation of the Notch-RBPJ signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is fine-tuned via its interactors and modifications is still largely unknown. In this study, using a proteomic approach, we ide...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034938 | Pride
Rbpj Notch signaling Ubiquitination 
ProteomicsEnrichment of NICD4 interacting proteins by three different methods.
There are several methods to bring down the bait and interactors from the cell lysates, each with its own advantages and disadvantages. Recently, the most commonly used method is one step AP, TAP and proximity-labeling. In order to analyze the Strengths and weaknesses of the three methods, fusion pr...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031772 | Pride
Sfb-tap Nicd4 Flag tag ap Turboid. 
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