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TranscriptomicsCo-culture of human hematopoietic stem cells with osteoblasts affects mono/macrophage versus erythroid lineage choice.
Hematopoietic stem cells (HSCs) are located in the bone marrow in a specific microenvironment referred as the hematopoietic stem cell niche, where HSCs interact with a variety of stromal cells. Though several components of the stem cell niche have been identified, the regulatory mechanisms through w...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-38091 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD34+ progenitor cells
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb in human hematopoietic lineage commitment, we studied the effects of its silencing during the commitment of human CD34+ Hematopoietic stem/progeni...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-13110 | biostudies-arrayexpress
TranscriptomicsMYB silencing in CD14-myeloblasts
The c-Myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To define the role of c-Myb during the terminal differentiation of hematopoietic precursors, we studied the effects of its silencing in human primary CD14-myeloblasts, which ...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-21943 | biostudies-arrayexpress
UnknownCardiac pacing in severe recurrent reflex syncope and tilt-induced asystole.
Not available
S-EPMC7857694 | biostudies-literature
TranscriptomicsTranscription profiling of human CD43+ cells from idiopathic myelofibrosis patients vs normal individuals identifies a set of disease-associated genes and reveals the clinical significance of Wilms tumor gene 1 (WT1)
IM CD34+ vs BM CD34+ cells Experiment Overall Design: Differential gene expression profiling of CD34+ cells purified from the PB of 15 IM patients (3 distinct pools) and from the BM of 15 healthy subjects (3 distinct pools)
ORGANISM(S): Homo sapiens 
2007-11-08 | E-GEOD-3410 | biostudies-arrayexpress
TranscriptomicsExpression data from untreated and valproic acid (VPA) treated CD34+ Hematopoietic Stem Cells (HSCs)
Histone deacetylase (HDAC) inhibitors are widely utilized in hematopoietic malignance therapy; nevertheless, little is currently known concerning their effects on normal myelopoiesis. In order to investigate a putative interference of HDAC inhibitors in myeloid commitment of hematopoietic stem/proge...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-31283 | biostudies-arrayexpress
TranscriptomicsHuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA (miRNA)
Upon muscle injury the high mobility group box 1 (HMGB1) protein is up-regulated and secreted to initiate reparative responses. Here we show that HMGB1 controls myogenesis both in vitro and in vivo, during development and after adult muscle injury. HMGB1 expression in muscle cells is regulated at th...
ORGANISM(S): Mus musculus 
2013-08-14 | E-GEOD-49855 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human Caco-2 cells treated with a nutraceutical formula (solution-10), or vehicle-(saline solution)- control
Caco-2 cells were plated (1x106 cells) and treated with a nutraceutical formula (Solution-10) at 0.01x concentration or with vehicle (saline solution) as the negative control for the treatment. After 24 hours, the cells were lysed, and their RNA was extracted for RNAseq.
ORGANISM(S): Homo sapiens 
2026-08-14 | E-MTAB-17520 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human HEK-293T cells treated with a nutraceutical formula (solution-10), or vehicle-(saline solution)- control
HEK-293T cells were plated (1x106 cells) and treated with a nutraceutical formula (Solution-10) at 0.01x concentration or with vehicle (saline solution) as the negative control for the treatment. After 24 hours, the cells were lysed, and their RNA was extracted for RNAseq.
ORGANISM(S): Homo sapiens 
2026-08-14 | E-MTAB-17521 | biostudies-arrayexpress
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