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GenomicsPPARγ agonists induce biased signaling in human adipocytes
PPARγ agonists induce biased signaling in human adipocytes
PRJNA1105894 | ENA
ProteomicsMapping AT1R biased signaling using proximity-labeling and proteomics identifies diverse actions of biased agonists
Angiotensin II type 1 receptors (AT1Rs) are one of the most widely studied G protein-coupled receptors. To fully appreciate the diversity in cellular signaling profiles activated by AT1R transducer-biased ligands, we utilized peroxidase-catalyzed proximity labeling to capture proteins in close prox...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD023814 | Pride
Apex Proximity labeling At1r Biased agonism 
ProteomicsIntrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
G protein-coupled receptors (GPCRs) are typically characterized by their seven transmembrane (7TM) architecture, and interaction with two universal signal-transducers namely, the heterotrimeric G-proteins and β-arrestins (βarrs). Synthetic ligands and receptor mutants have been designed to elicit tr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027887 | Pride
Gpcr kinases Gpcrs Β-arrestins Complement c5a Biased signaling Β-arrestin-coupled receptors Seven transmembrane receptors 
UnknownGPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization.
Not available
S-EPMC10927030 | biostudies-literature
UnknownCB1 Cannabinoid Receptor Signaling and Biased Signaling.
Not available
S-EPMC8433814 | biostudies-literature
TranscriptomicsPPARγ agonists induce biased signaling in human adipocytes
Biased signaling and ligand bias, often referred to as functional selectivity or selective nuclear receptor modulation, have been reported for many nuclear receptor partial agonists over the past 20 years. However, whether differences in nuclear receptor signaling produced by partial and full agonis...
ORGANISM(S): Homo sapiens 
2025-10-26 | GSE266107 | GEO
TranscriptomicsMyeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence
Tissue stem cells are hierarchically organized, but the signals that selectively preserve their functional integrity are largely unknown. Semaphorin 4A (Sema4A) is a specific regulator of myeloid-biased hematopoietic stem cells (myHSC), which are positioned at the top of the HSC hierarchy. Through s...
ORGANISM(S): Mus musculus 
2023-06-04 | E-MTAB-12890 | biostudies-arrayexpress
UnknownG protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons.
Not available
S-EPMC6373773 | biostudies-literature
GenomicsNf2 orchestrates β-arrestin2-biased PTH1R signaling to safeguard skeletal integrity
Nf2 orchestrates β-arrestin2-biased PTH1R signaling to safeguard skeletal integrity
PRJNA1422208 | ENA
UnknownA calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.
Not available
S-EPMC6166785 | biostudies-literature
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