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ProteomicsExperiment of proteomics and S-nitrosylation modifications proteomics in the hearts of HFpEF mice
We established a mouse model of HFpEF using 8-12-week-old male C57BL/6J mice, and conducted proteomic and nitrosylation modification profiling on the hearts of the control group (n=5) and the HFpEF mice (n=5) to determine the phenotypic changes.
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD075362 | Pride
Hfpef Heart S-nitrosylation Mouse Post-translational modification Proteomics Lc-ms/ms 
ProteomicsLamin A/C-regulated cysteine catabolic flux orchestrates cell fate through epigenome reprogramming
Spatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet their interplay is poorly understood. Here, we identify lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity. Its loss in naïve pluripotent stem cells upregulates CTH...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-04 | PXD071040 | Pride
Acetylation Histones Lmna 
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