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TranscriptomicsTranscription profiling of mouse CD11b cells purified from mouse spleen from umor-free and tumor-bearing mice
Active suppression of tumor-specific T lymphocytes can limit the immune-surveillance and immunotherapy efficacy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governi...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-5455 | biostudies-arrayexpress
TranscriptomicsshRNAi profiling of human MDA-MB-231 cells expressing anti-p53 (shp53) short-hairpin RNAs treated with TFGbeta or control
TGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers. The molecular nature of this switch remains enigmatic. We now show that TGFβ-dependent cell migration, invasion and metastasis are empowered by mutant-p...
ORGANISM(S): Homo sapiens 
2009-04-11 | E-GEOD-14491 | biostudies-arrayexpress
TranscriptomicsRole of TAZ as mediator of Wnt signaling
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-39907 | biostudies-arrayexpress
TranscriptomicsMolecular and cellular characterization of Cord Blood derived, IDO expressing human fibrocystic Myeloid Derived Suppressor Cells
By restraining T cell activation and promoting regulatory T cell (Treg) expansion, myeloid-derived suppressor cells (MDSC) and tolerogenic dendritic cells (DC) (tDC) can control self-reactive and anti-graft effector T cells in autoimmunity and transplantation. Their therapeutic use and characterizat...
ORGANISM(S): Homo sapiens 
2014-08-26 | E-GEOD-52376 | biostudies-arrayexpress
TranscriptomicsExpression data from bone marrow derived- and tumor induced- CD11b+ MDSC
Tumor growth is associated with a profound alteration of myelopoiesis, leading to recruitment of immunosuppressive cells known as myeloid-derived suppressor cells (MDSCs). Analyzing the cytokines affecting myelo-monocytic differentiation produced by various experimental tumors, we found that GM-CSF...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-21927 | biostudies-arrayexpress
TranscriptomicsRole of TAZ as mediator of Wnt signaling (SW480)
To investigate the role of TAZ downstream of the abberrant Wnt signaling in CRC cells, we compared the expression profiles of parental SW480 cells (empty vector) transfected with siControl, siTAZ, sibeta-catenin or reconstituted with wild type APC and transfected with siControl Keywords: expression...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-39904 | biostudies-arrayexpress
TranscriptomicsRole of TAZ as mediator of Wnt signaling (MII)
To investigate the role of TAZ downstream of APC and beta-catenin in mammary epithelial cells cells, we compared the expression profiles of MCF10-T1k (MII) cells transfected with siControl, siAPC, siAPC+siTAZ, sibeta-catenin, or sibeta-catenin+siTAZ. Keywords: expression profiling by array We colle...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-39902 | biostudies-arrayexpress
TranscriptomicsGenome-wide Definition of Promoter and Enhancer Usage During Neural Induction of Human Embryonic Stem Cells [CAGE-seq]
Genome-wide mapping of transcriptional regulatory elements are essential tools for the understanding of the molecular events orchestrating self-renewal, commitment and differentiation of stem cells. We combined high-throughput identification of nascent, Pol-II-transcribed RNAs by Cap Analysis of Gen...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-61264 | biostudies-arrayexpress
TranscriptomicsGenome-wide Definition of Promoter and Enhancer Usage During Neural Induction of Human Embryonic Stem Cells [gene expression profile]
Genome-wide mapping of transcriptional regulatory elements are essential tools for the understanding of the molecular events orchestrating self-renewal, commitment and differentiation of stem cells. We combined high-throughput identification of nascent, Pol-II-transcribed RNAs by Cap Analysis of Gen...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-61266 | biostudies-arrayexpress
TranscriptomicsComparative Genomics Reveals New Molecular targets for Accelerated Improvement of Erythromycin-producing Strains
Information about molecular mechanisms underlying improvement of antibiotic-producing microorganisms with traditional mutation and screening approach is largely missing. This information is essential to develop rational approaches to strain improvement. In this study by using comparative genomic ana...
ORGANISM(S): Saccharopolyspora erythraea 
2012-05-23 | E-GEOD-30600 | biostudies-arrayexpress
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