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TranscriptomicsExperimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high resolution tiling arrays
Compared to other model organisms and despite the clinical relevance of the pathogenic yeast Candida albicans, no comprehensive analysis has been done to provide experimental support of its in silico-based genome annotation. Here we have undertaken a genome-wide experimental annotation to accurately...
ORGANISM(S): Candida albicans 
2010-07-07 | E-GEOD-22625 | biostudies-arrayexpress
TranscriptomicsmiRNA Expression In Maintenance and Differentiation of Human Embryonic Stem Cells
Recent advances in the study of human embryonic stem cells (hESCs) and induced-pluripotent stem cells (iPS) highlight their importance as both model systems for basic research and avenues for therapeutic applications. To gain better insight into these cells, a clearer understanding of their molecul...
ORGANISM(S): Homo sapiens 
2010-09-09 | E-GEOD-14473 | biostudies-arrayexpress
TranscriptomicsA Common Docking (CD) Domain in Progesterone Receptor-B Links MKP3-Dependent Rapid Signaling Events to JAK/STAT Regulation of Gene Expression Required for Breast Cancer Cell Proliferation
Progesterone receptors (PRs) are critical context-dependent transcription factors required for normal uterine (PR-A) and mammary gland (PR-B) development. Progesterone is proliferative in the breast, where PR-target genes include paracrine factors that mediate mammary stem cell self-renewal. In the ...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-46850 | biostudies-arrayexpress
TranscriptomicsRNA profiles of embryonic stem cells generated from in vitro produced or in vivo derived rhesus preimplantation embryos
It is often overlooked that human ESCs are generated from in vitro cultured, often surplus/‘discard’, embryos considered unsuitable for transfer in infertility clinics. In vitro culture of preimplantation embryos has been associated with a number of perturbations, including ultrastructure, gene expr...
ORGANISM(S): Macaca mulatta 
2010-11-09 | E-GEOD-25198 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pig aortic valve exposure to two levels of cyclic mechanical pressure reveals mechanosensitive signalling pathways
Multiple molecular and cellular mechanisms are associated with the initiation and progression of aortic valve disease. Alterations in ECM remodeling, increased expression of pro-inflammatory cytokines, calcification, lipid deposition and changes in valve cell phenotype have demonstrated roles in dev...
ORGANISM(S): Sus scrofa 
2009-03-25 | E-GEOD-15211 | biostudies-arrayexpress
TranscriptomicsFibronectin regulates Wnt7a signaling and satellite cell expansion
The influence of the extracellular matrix (ECM) within the stem cell niche remains poorly understood. We found that Syndecan-4 (Sdc4) and Frizzled-7 (Fzd7) form a coreceptor complex in satellite cells and that binding of the ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a t...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59272 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse CD3+ T-cells from WT and KLF13 KO mice
Kruppel-like factors are a subclass of zinc finger transcription factors that play important roles in different aspects of cell growth, development, and differentiation. Our group have identified KLF13 as an essential transcription factor for the late expression of chemokine RANTES in T lymphocytes....
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-50617 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human breast cancer cell lines (45) on Affymetrix 100K SNP arrays
Breast cancer cell lines grown in full serum under standard conditions were profiled on Affymetrix GeneChip Mapping 100K Set Arrays Experiment Overall Design: Profiling of cell lines grown under standard conditions
ORGANISM(S): Homo sapiens 
2009-05-01 | E-GEOD-13696 | biostudies-arrayexpress
TranscriptomicsAnalysis of Gene Expression changes in human intestinal endothelial-to-mesenchymal transition - UNTREATED/CONTROL GROUP
Intestinal fibrosis is a well-known complication of inflammatory bowel disease (IBD) and has important clinical implications for both forms of IBD, Crohn's disease (CD) and ulcerative colitis (UC). In addition to mesenchymal cells, endothelial cell contribute to organ fibrosis through the process o...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-15933 | biostudies-arrayexpress
TranscriptomicsAnalysis of Gene Expression changes in human intestinal endothelial-to-mesenchymal transition - TRANSFORMED GROUP
Intestinal fibrosis is a well-known complication of inflammatory bowel disease (IBD) and has important clinical implications for both forms of IBD, Crohn's disease (CD) and ulcerative colitis (UC). In addition to mesenchymal cells, endothelial cell contribute to organ fibrosis through the process o...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-15934 | biostudies-arrayexpress
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