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Proteomicsplasma membrane anchored NAA60 N-terminal acetylation profiling in Arabidopsis thaliana
N-terminal acetylation (NTA) is one of the most abundant protein modifications in eukaryotes and is catalysed in humans by seven N-acetyltransferases. AtNAA60 localizes to the plasma membrane in vivo by an α-helical membrane anchor at its C-terminus. In this study, we investigated the Arabidopsis th...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-07-15 | PXD016494 | Pride
Acetyltransferase N-acetylome N-terminal acetylation Quantitative proteomics Silpronaq 
ProteomicsTracking the N-Myristoylated N-termini in human cell line lysates (soluble fraction) to highlight this protein modification at the proteome level
Characterization of N-Myristoylated proteins in the soluble fraction of four human cell lines (HUVEC, U87, K562 and HCT116) using large-scale proteomics approaches.
ORGANISM(S): Homo sapiens (Human) 
2018-06-18 | PXD008666 | Pride
Myristoylation N-myristoyltransferase N-terminus N-acetylation Methionine excision S-palmitoylation 
ProteomicsProteome imprinting by N-terminal acetylation is a vital hormone-regulated master switch during stress
N-terminal acetylation (NTA) catalyzed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Characterization of the plant NatA complex reveals evolutionary conservation of NatA biochemical properties within hig...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-06-14 | PXD002069 | Pride
Abscisic acid Embryogenesis Drought resistance N-terminal protein acetylation 
ProteomicsProteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state
A proteome-wide analysis was performed in Escherichia coli to identify the impact on protein N-termini of the antibiotic actinonin specifically inhibiting peptide deformylase (PDF). A new strategy and tool suite (SILProNaQ) was employed to provide large scale N-terminus acetylation yield quantitatio...
ORGANISM(S): Escherichia coli 
2015-07-22 | PXD001983 | Pride
Formylation/post-translational modifications/actinonin/acetylation/antibiotics 
ProteomicsGlobal acetylation profiling for the Arabidopsis thaliana plasma membrane anchored NAA60 N-terminal acetyltransferase
N-terminal acetylation is one of the most abundant protein modifications in eukaryotes and is catalysed in humans by seven N-terminal acetyltransferases. AtNAA60 is localized in vivo at the plasma membrane by an α-helical membrane anchor at its C-terminus. In this study, we investigated the Arabidop...
ORGANISM(S): Escherichia coli 
2020-07-15 | PXD016533 | Pride
Acetyltransferase N-acetylome N-terminal acetylation Quantitative proteomics Silpronaq Gap test 
ProteomicsProteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state and upon deformylation inhibition
A proteome-wide analysis was performed in Escherichia coli to identify the impact on protein N-termini of the antibiotic actinonin specifically inhibiting peptide deformylase (PDF). A new strategy and tool suite (SILProNaQ) was employed to provide large scale N-terminus acetylation yield quantitatio...
ORGANISM(S): Escherichia coli 
2015-07-21 | PXD002012 | Pride
Antibiotics Post-translational modifications Acetylation Actinonin Formylation 
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