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ProteomicsN-Myristoyltransferase inhibition in HeLa
N-Myristoyltransferase (NMT) covalently attaches a C14-fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We used quantitative proteomics to map protein expression changes for more than 2700 proteins in response to treatment with an NMT inhibito...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080783 | MassIVE
ProteomicsN-Myristoyltransferase inhibition in HeLa
N-Myristoyltransferase (NMT) covalently attaches a C14-fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We used quantitative proteomics to map protein expression changes for more than 2700 proteins in response to treatment with an NMT inhibito...
ORGANISM(S): Homo sapiens (Human) 
2016-06-13 | PXD003186 | Pride
Hela N-myristoyltransferase inhibition Q-exactive Spike-in silac 
ProteomicsQuantitative TMT proteomics of myristoylated proteins in Trypanosoma cruzi and human cardiomyocytes during N-myristoyltransferase inhibition
This project investigates the impact of N-myristoyltransferase (NMT) inhibition on the myristoylated proteome of Trypanosoma cruzi and human cardiomyocytes in the context of Chagas disease. Human AC16 cardiomyocytes were infected with T. cruzi (CL Brener strain) and treated with the reference NMT in...
ORGANISM(S): Trypanosoma cruzi Homo sapiens (Human) 
2026-01-26 | PXD071927 | Pride
N-myristoyltransferase N-myristoylation Tmt sixplex Orbitrap exploris 240 Chagas disease Ac16 cardiomyocytes Trypanosoma cruzi Click chemistry Quantitative proteomics Lc–ms/ms 
UnknownN-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Not available
S-EPMC2917743 | biostudies-literature
UnknownValidation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
Not available
S-EPMC4739506 | biostudies-literature
UnknownInhibition of N-myristoyltransferase activity promotes androgen receptor degradation in prostate cancer.
Not available
S-EPMC10872856 | biostudies-literature
UnknownA fluorescence-based assay for N-myristoyltransferase activity.
Not available
S-EPMC3863716 | biostudies-literature
UnknownHigh-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Not available
S-EPMC7048800 | biostudies-literature
UnknownStructure-guided optimization of quinoline inhibitors of <i>Plasmodium N</i>-myristoyltransferase.
Not available
S-EPMC5463734 | biostudies-literature
UnknownDesign and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
Not available
S-EPMC5734605 | biostudies-literature
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