Elevated exposure to 4-hydroxyphenanthrenes (4-OHPhe) is positively associated with obesity risk. However, the specific pathogenic mechanism remains unclear. Here, we used SHapley Additive exPlanations (SHAP) and logistic regression analysis to identify a strong association between 4-OHPhe and o...

Introduction:

Bariatric surgery profoundly improves type 2 diabetes (T2D); however, the specific mechanisms linking distinct procedures to metabolic benefits through bile acid (BA) remodeling remain incompletely understood. This study investigates the differential effects of single-anastomo...

Introduction:

Bariatric surgery profoundly improves type 2 diabetes (T2D); however, the specific mechanisms linking distinct procedures to metabolic benefits through bile acid (BA) remodeling remain incompletely understood. This study investigates the differential effects of single-anastomo...

BACKGROUND: Intestinal bacteria are known to regulate the bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulating the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regula...

This study aims to compare changes in bile acid profiles between fecal samples from rats fed a standard control diet and those fed a high-fat diet.

Upon reaching an OD600 of 0.3, L.

reuteri cultures were treated with 100 µM TCA, HCA, or

TCDCA. For BSHs inhibition assays, additional wells were treated with 100 µM

HCA + GR7. Both negative control and MRS medium control groups were included.

Cultures were terminated at 7...

This study investigated the regulatory effects of three probiotics (P. pentosaceus, B. coagulans, and E. faecalis) on bile acid metabolism in common carp (Cyprinus carpio) fed a high-carbohydrate-high-fat (HCHF) diet for 56 days. A targeted metabolomics approach using UHPLC-QTRAP-MS/MS with sched...

The co-occurrence of gut microbiota dysbiosis and bile acids (BAs) metabolism alteration has been reported in several human liver diseases. However, the gut microbiota dysbiosis in infantile cholestatic jaundice (CJ), and the linkage between gut bacterial changes and alterations of BAs metabolism...

Introduction: Guanxinning tablet (GXNT), a traditional Chinese medicine preparation, has been found to improve lipid metabolism in patients with cardiovascular disease. However, the underlying mechanisms are still poorly understood. This study aims to determine whether the gut micr...