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ProteomicsFast and robust proteome screening platform identifies neutrophil extracellular trap formation in the lung in response to cobalt ferrite nanoparticles
The goal of this study was to investigate the effects of magnetic iron cobalt oxide nanoparticles (cobalt doped Fe3O4 nanoparticles with increasing amounts of cobalt) after pulmonary exposure while in parallel presenting a proteomics platform that is easily transferable to large-scale nanotoxicology...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-26 | PXD016148 | Pride
Tmt Iron cobalt oxide nanoparticles Balf Lung Clinical proteomics Nanoparticles Mouse Murine Label-free Metal oxide nanoparticles Bronchoalveolar lavage fluid 
ProteomicsRecessive variants in the intergenic NOS1AP-C1orf226 locus cause monogenic kidney disease responsive to anti-proteinuric treatment
In genetic disease, an accurate expression landscape of disease genes and faithful animal models will enable precise genetic diagnoses and therapeutic discoveries, respectively. We previously discovered that variants in NOS1AP, encoding nitric oxide synthase 1 (NOS1) adaptor protein, cause monogenic...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD058044 | Pride
Mice Kidney Newborn 
ProteomicsMetabolic reconfiguration through SGLT2 inhibition improves metabolic waste excretion
Dapagliflozin is a member of a new class of medication called gliflozins indicated for the treatment of diabetes and has recently been also approved for the treatment of kidney and heart diseases. Gliflozins lower blood glucose levels by inhibition of the sodium glucose co-transporter 2 (SGLT2), whi...
ORGANISM(S): Mus musculus (Mouse) mouse gut metagenome 
2026-02-09 | PXD036817 | Pride
White adipose tissue Kidney Heart Skeletal muscle Lc-ms/ms Dapagliflozin Mouse Tmt Exploris 480 Murine Sglt2 inhibitors Liver Gut microbiome 
ProteomicsComprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from multiple tissues but require invasive harvesting and imply donor-to-donor variability. Embryonic stem cell-derived MS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080827 | MassIVE
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