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ModelsWei2022 - HobPre: accurate prediction of human oral bioavailability for small molecules
HobPre predicts the oral bioavailability of small molecules in humans. It has been trained using public data on ~1200 molecules (Falcón-Cano et al, 2020, complemented with other literature and ChEMBL compounds). Model Type: Predictive machine learning model. Model Relevance: Predicts Probability of...
2024-06-03 | MODEL2406030001 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
ProteomicsMolecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability
Priapism is a disorder in which prolonged penile erection persists uncontrollably, potentially leading to tissue damage. Priapism commonly afflicts patient populations with severely low nitric oxide (NO) bioavailability. As NO is a primary mediator of erection, the molecular mechanisms involved in p...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-13 | PXD007713 | Pride
Priapism Proteomics Nitric oxide Erectile Mass spectrometry Penis Pka Gpcr 
ProteomicsIntracellular drug bioavailability: impact of neutral lipids and phospholipids
The intracellular unbound drug concentration (Cu,cell) drives pharmacological and toxicological responses for targets inside cells. We have previously shown that Cu,cell is not always equal to extracellular unbound drug concentrations (e.g. plasma concentrations). However, the underlying mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD008994 | Pride
Proteomics Phospholipids 3t3-l1 Lipids Drug binding Intracellular drug bioavailability Membrane partitioning 
TranscriptomicsDifferential Gene Expression in Daphnia magna Suggests Distinct Modes of Action and Bioavailability for ZnO nanoparticles and Zn ions
Zinc Oxide nanoparticles (ZnO NPs) are being rapidly developed for use in consumer products, wastewater treatment and chemotherapy providing several possible routes for ZnO NP exposure to humans and aquatic organisms. Recent studies have shown that ZnO NPs undergo rapid dissolution to Zn+2, but the...
ORGANISM(S): Daphnia magna 
2010-12-31 | E-GEOD-22051 | biostudies-arrayexpress
UnknownBioavailability of Oral Hydrocortisone Corrected for Binding Proteins and Measured by LC-MS/MS Using Serum Cortisol and Salivary Cortisone.
Not available
S-EPMC5963674 | biostudies-literature
ProteomicsNATCANCER-A16341B 1 2 iNV GOV 3 4GOV
Oncolytic viruses (OVs) are replication-competent viruses that selectively infect tumor cells and induce anti-tumor responses. However, systemic delivery is limited by neutralizing antibodies and poor intratumoral bioavailability. We developed iNV-GOV, a tumor-targeted, low-immunogenic platform that...
ORGANISM(S): Homo sapiens (Human) 
2025-10-03 | PXD067837 | Pride
Inv gov and gov 
GenomicsSubstitution of polysorbates by plant-based emulsifiers: impact on vitamin D bioavailability and gut health in mice
Substitution of polysorbates by plant-based emulsifiers: impact on vitamin D bioavailability and gut health in mice
PRJEB89673 | ENA
GenomicsIGFBP3 Promotes Mammary Stem Cells Activity and Tumorigenesis by Regulating IGF Bioavailability
IGFBP3 Promotes Mammary Stem Cells Activity and Tumorigenesis by Regulating IGF Bioavailability
PRJNA1227909 | ENA
ClinicalA Performance and Bioavailability Study of Entrectinib in Healthy Volunteers.
This study will evaluate the bioavailability, palatability, safety and tolerability of entrectinib in healthy volunteers. Part 1 of the study will explore the performance of entrectinib multi-particle formulation. Part 2 will evaluate the effect of drug substance particle size on entrectinib bioavai...
2306412 | ecrin-mdr-crc
Genomics
GEREMIA DOM bioavailability in coastal area
PRJNA952911 | ENA
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