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TranscriptomicsHierarchical regulation in a KRAS-dependent transcriptional network revealed by a reverse-engineering approach
Mutations in RAS proteins occur in 30% of human tumours and have a high relevance in tumor progression. Despite the importance of the underlying genetic network that governs the effects of oncogenic RAS, it is still poorly understood. We developed and applied a reverse-engineering approach in order ...
ORGANISM(S): Rattus norvegicus 
2011-03-01 | E-GEOD-24668 | biostudies-arrayexpress
UnknownSystematic reverse engineering of network topologies: a case study of resettable bistable cellular responses.
Not available
S-EPMC4149494 | biostudies-literature
UnknownThe gene regulatory network of mESC differentiation: a benchmark for reverse engineering methods.
Not available
S-EPMC5974445 | biostudies-literature
UnknownReverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction.
Not available
S-EPMC11522409 | biostudies-literature
TranscriptomicsHierarchical regulation in a KRAS pathway-dependent transcriptional network revealed by a reverse-engineering approach (RAS-ROSE and ROSE with siRNA)
RAS mutations are highly relevant for progression and therapy response of human tumours, but the genetic network that ultimately executes the oncogenic effects is poorly understood. Here we used a reverse-engineering approach in an ovarian cancer model to reconstruct KRAS oncogene-dependent cytoplas...
ORGANISM(S): Rattus norvegicus 
2012-07-31 | E-GEOD-38585 | biostudies-arrayexpress
TranscriptomicsReverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL
The TLX1 and TLX3 transcription factor oncogenes play an important role in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL)1,2. Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3. This Systems Bi...
ORGANISM(S): Mus musculus 
2011-11-08 | E-GEOD-33550 | biostudies-arrayexpress
UnknownSJARACNe: a scalable software tool for gene network reverse engineering from big data.
Not available
S-EPMC6581437 | biostudies-literature
TranscriptomicsTranscription profiling of human T-ALL cell cultures treated with Compound E, a gamma-secretase inhibitor or vehicle only (DMSO) for 24 h
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T-cell development and in the pathogenesis over 50% of human T-cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcrip...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5827 | biostudies-arrayexpress
TranscriptomicsExpression data from inducible ES stable cell line
In order to identify the effects of the induction of the gene of interest on the mouse ES transcriptome, we performed Affymetrix Gene-Chip hybridization experiments for the inducible not-tagged cell line. Transcriptome analysis of the inducible transgenic mouse ES cell line. The E13 inducible cell l...
ORGANISM(S): Mus musculus 
2012-12-13 | E-GEOD-31166 | biostudies-arrayexpress
UnknownReverse engineering of modified genes by Bayesian network analysis defines molecular determinants critical to the development of glioblastoma.
Not available
S-EPMC3667850 | biostudies-literature
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