Sort   by:  
 Page size 
MetabolomicsSex-dependent metabolic remodeling of kidneys revealed by arteriovenous metabolomics

Sex is a fundamental biological variable important in biomedical research, drug development, clinical trials, and prevention approaches. Among many organs, kidneys are known to exhibit remarkable structural, histological, and pathological differences between sexes. However, whether and how kidney...

2026-03-04 | MTBLS13977 | MetaboLights
MetabolomicsMulti-Omics Profiling Reveals Sex-Stratified Biomarkers Predicting Chronicity in Pediatric Primary Immune Thrombocytopenia

Primary immune thrombocytopenia (ITP) is recognized as an acquired autoimmune hemorrhagic disorder distinguished by diminished platelet counts. The efficacy of a sex-stratified multi-omics integrative analytical strategy for forecasting pediatric ITP chronicity was proposed and validated in this ...

2025-09-01 | MTBLS12920 | MetaboLights
MetabolomicsKynurenic acid underlies sex-specific immune responses to COVID-19
Sex-related differences in Coronavirus Disease (COVID-19) severity and mortality exist, with the male sex being a potential risk factor1. It was recently shown that patients with mild to moderate SARS-CoV-2 infection have elevated levels of inflammatory cytokines and chemokines, and sex-differences ...
2020-09-08 | MTBLS1987 | MetaboLights
MetabolomicsCryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues
OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS boosts ioni...
2023-03-15 | MTBLS1873 | MetaboLights
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
MetabolomicsA molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.
Unlike chronological age, biological age is a strong indicator of health of an individual. However, the molecular fingerprint associated with biological age is ill-defined. To define a high-resolution signature of biological age, we analyzed metabolome, circulating senescence-associated secretome (S...
2024-01-24 | MTBLS1991 | MetaboLights
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
GenomicsUnbiased, Genome-wide in vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-specific Liver Gene Expression
We have used a simple and efficient method to identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular basis of sex-differences in transcription, which are widespread in mammalian tissues and affect normal physiology, drug response, inflammation and diseas...
ORGANISM(S): Mus musculus 
2010-09-28 | E-GEOD-21777 | biostudies-arrayexpress
TranscriptomicsSex of Blood
Blood samples were taken at 1:00 pm +/- 1 h (Potassium-EDTA-monovettes, Sarstedt, Numbrecht, Germany) to control for circadian influences on gene expression. Blood was taken from normal male controls, normal female controls as well as different patients with disorders of sex development leading to a...
ORGANISM(S): Homo sapiens 
2009-07-13 | E-GEOD-11235 | biostudies-arrayexpress
MetabolomicsSex-Driven Differences in the Rumen Microbe-Metabolite-Epithelial Transport Axis: An Integrated Multi-Omics Study of Rumen Function in Male and Female Zhongwei Goats
This study investigates sex-driven differences in rumen metabolism in male and female Zhongwei goats. Rumen fluid samples were analyzed using untargeted LC-MS metabolomics in both positive and negative ion modes. Metabolites were separated by ultra-high-performance liquid chromatography and detected...
2026-08-31 | MTBLS15319 | MetaboLights
Sort   by:  
 Page size