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MetabolomicsLipidomic analysis reveals altered lipid profiles of clinically healthy and periodontitis-affected gingival biopsies

AIM: The role of lipids in periodontitis has not been well studied. Thus, this study aimed to explore periodontitis-associated lipid profile changes and identify differentially expressed lipid metabolites in gingival tissues.

MATERIALS AND METHODS: Gingival...

2022-08-19 | MTBLS4684 | MetaboLights
TranscriptomicsNext-Generation Transcriptome Sequencing (RNA-Seq) of Human Endobronchial Biopsies: Asthma vs Controls
Rationale: The cellular and molecular pathways in asthma are highly complex. Increased understanding can be obtained by unbiased transcriptomic analysis (RNA-Seq). Hypothesis and Aims: We hypothesized that the transcriptomic profile of whole human endobronchial biopsies differs between patients with...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-38994 | biostudies-arrayexpress
TranscriptomicsThe effect of cortex/medulla proportions on molecular diagnoses in kidney transplant biopsies: rejection and injury can be assessed in medulla
Histologic assessment of kidney transplant biopsies relies on cortex rather than medulla, but for microarray studies, the proportion cortex in a biopsy is typically unknown and could affect the molecular readings. The present study aimed to develop a molecular estimate of proportion cortex in biopsi...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-GEOD-95611 | biostudies-arrayexpress
TranscriptomicsExpression data from human renal allograft biopsies to investigate renal transplant rejection and failure
Kidney transplants that develop dysfunction or proteinuria after one year post transplant are at considerable risk for progression to renal failure. Identifying the molecules associated with graft failure could potentially lead to interventions that would slow the progression of organ failure. We an...
ORGANISM(S): Homo sapiens 
2010-05-24 | E-GEOD-21374 | biostudies-arrayexpress
TranscriptomicsAssessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes
Molecular phenotyping of biopsies affords opportunities for increased precision and improved disease classification to address the limitations of conventional histologic diagnostic systems. We applied archetypal analysis, an unsupervised method similar to cluster analysis, to microarray data from 12...
ORGANISM(S): Homo sapiens 
2017-07-10 | E-GEOD-98320 | biostudies-arrayexpress
ProteomicsHuman colon biopsies (healthy and Ulcerative Colitis) LC-MS/MS
The etiology of the inflammatory bowel diseases, including ulcerative colitis, remains incomplete, but recent findings points to the involvement of complex host-microbial interactions. We hypothesized that an analysis of the proteins on the host-microbial interacting surface, the intestinal mucosa, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080833 | MassIVE
ProteomicsProteomic characterization of human hepatocellular carcinoma (HCC) tumor biopsies
We analyzed the proteome of tumor and matched non-tumor biopsies from 51 treatment-naive Hepatocellular carcinoma (HCC) patients by DIA (SWATH). Thereby we aim to find subgroups of patients characterized by specific pathway activation. Furthermore, we aim to find novel factors involved in HCC develo...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD025705 | Pride
Human Swath Biopsies Hcc 
ProteomicsComparative proteome stability analysis of snap frozen, RNAlater preserved, and formalin-fixed paraffin-embedded human colon mucosal biopsies
Clinical proteomics research is in part limited by the availability of clinical samples. However, large biobanks exist worldwide containing formalin-fixed and paraffin embedded samples and samples stored in RNAlater. The extraction of proteins for proteome analysis from samples prepared by either me...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080863 | MassIVE
ProteomicsAscending colon biopsies from pediatric patients
We sought to identify proteins that enable differentiation between CD and UC in children with new onset IBD. Mucosal biopsies were obtained from children undergoing baseline diagnostic endoscopy prior to therapeutic interventions. Using a super-stable isotope labeling with amino acids in cell cultur...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD005086 | Pride
Colon Lcmsms 
TranscriptomicsAnalyses of heterogeneous renal allograft biopsies reveal conserved rejection signatures and molecular pathways I, partB
Specific early diagnosis of renal allograft rejection is gaining importance in the current trend to minimize and individualize immunosuppression. Gene expression analyses could contribute significantly by defining M-bM-^@M-^\molecular BanffM-bM-^@M-^] signatures. Several previous studies have applie...
ORGANISM(S): Homo sapiens 
2009-08-27 | E-GEOD-17861 | biostudies-arrayexpress
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