Sort   by:  
 Page size 
MetabolomicsStreamlined identification of strain engineering targets for bioprocess improvement using metabolic pathway enrichment analysis
Metabolomics is a powerful tool for the identification of genetic targets for bioprocess optimisation. However, in most cases, only the biosynthetic pathway directed to product formation is analysed, limiting the identification of these targets. Some studies have used untargeted metabolomics, allowi...
2023-08-31 | MTBLS6667 | MetaboLights
MetabolomicsEnzyme engineering for optimizing biosynthesis of 2,4-dihydroxybutyric acid via the synthetic threose-dependent glycolaldehyde assimilation (STEGA) pathway
Ethylene glycol is a potential feedstock for next-generation biorefineries, as it can be derived from both plastic waste and carbon dioxide. The synthetic D-threose-dependent glycolaldehyde assimilation (STEGA) pathway, which is orthogonal to central metabolism of Escherichia coli, was recently cons...
2026-07-15 | MTBLS15050 | MetaboLights
MetabolomicsFerritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights
TranscriptomicsGlobal analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways
The eubacterial species Streptomyces coelicolor proceeds through a complex growth cycle in which morphological differentiation/development is associated with a transition from primary to secondary metabolism and the production of antibiotics. We used DNA microarrays and mutational analysis to invest...
ORGANISM(S): Streptomyces coelicolor 
2005-07-23 | E-GEOD-2983 | biostudies-arrayexpress
TranscriptomicsCross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor
A complex programme of regulation governs gene expression during development of the morphologically and biochemically complex eubacterial genus Streptomyces. Earlier work has suggested a model in which 'higher level' pleiotropic regulators activate 'pathway-specific' regulators located within chromo...
ORGANISM(S): Streptomyces coelicolor 
2006-02-01 | E-GEOD-4138 | biostudies-arrayexpress
ProteomicsEngineering polyketide stereocenters with ketoreductase domain exchanges
Polyketide synthases (PKSs) are versatile biosynthetic megasynthases capable of producing a diverse range of natural products with many applications, including in pharmaceuticals. The stereochemical precision of PKSs makes them a powerful tool for engineering tailored, unnatural polyketides; however...
ORGANISM(S): Escherichia coli 
2025-12-01 | PXD066826 | Pride
Polyketide synthases (pks) protein engineering  kr swaps jbei 
UnknownBiosynthetic engineering of the antifungal, anti-MRSA auroramycin.
Not available
S-EPMC6943886 | biostudies-literature
TranscriptomicsReverse engineering of industrial pharmaceutical-producing actinomycete strains
Abstract: Transcript levels in production cultures of wildtype and classically improved strains of the actinomycete bacteria Saccharopolyspora erythraea and Streptomyces fradiae were monitored using microarrays of the sequenced actinomycete S. coelicolor. Sac. erythraea and S. fradiae synthesize the...
ORGANISM(S): Streptomyces coelicolor 
2006-03-08 | E-GEOD-4395 | biostudies-arrayexpress
MetabolomicsComplete pathway elucidation and heterologous reconstitution of Rhodiola salidroside biosynthesis
Salidroside is a bioactive tyrosine-derived phenolic natural product found in medicinal plants under the Rhodiola genus. In addition to their roles in traditional medicine as anti-fatigue and anti-anoxia adaptogens, Rhodiola total extract and salidroside have also displayed medicinal properties as a...
2018-01-25 | MTBLS566 | MetaboLights
MetabolomicsHigh-level de novo synthesis of medical plant derived flavonoid glycosides
Pichia pastoris is a widely used eukaryotic host for recombinant protein expression in biopharmaceutical and biomanufacturing, offering advantages such as broad carbon source utilization, high cell density, a mature fermentation process, and genomic stability. Recent advances in genetic editing and ...
2025-08-22 | MTBLS12177 | MetaboLights
Sort   by:  
 Page size