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MetabolomicsThe Crosstalk between Microbiota and Metabolites in AP Mice Based on Metagenomics and Untargeted Metabolomics

BACKGROUND AND PURPOSE: The microbiota dysfunction aggravated the severity of acute pancreatitis (AP), but the relationship between microbiota dysfunction and metabolites alteration was not fully explained. This study aimed to explore the crosstalk between microbiota and metaboli...

2023-08-10 | MTBLS6831 | MetaboLights
TranscriptomicsCatabolite repression of phosphoenolpyruvate carboxykinase by a zinc finger protein under biotin- and pyruvate carboxylase-deficient conditions in Pichia pastoris
We have identified a methanol- and biotin-starvation-inducible zinc finger protein named ROP [repressor of phosphoenolpyruvate carboxykinase (PEPCK)] in the methylotrophic yeast Pichia pastoris. When P.pastoris strain GS115 (wild-type, WT) is cultured in biotin-deficient, glucose ammonium (Bio-) ...
ORGANISM(S): Pichia pastoris 
2011-10-13 | E-GEOD-32948 | biostudies-arrayexpress
TranscriptomicsThe AP-1 Transcription Factor c-Jun Prevents Stress-Imposed Maladaptive Remodeling of the Heart
Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and ma...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-47898 | biostudies-arrayexpress
GenomicsGenome-wide maps of apurinic sites (AP-sites) and 8-oxoG derived secondary AP-sites
Genome-wide maps of apurinic sites (AP-sites) and 8-oxoG derived secondary AP-sites
PRJNA497112 | ENA
ProteomicsHuman Ku70 WT AP-MS - Mapping the Ku interactome using proximity-dependent biotin identification in human cells
Affinity purification coupled to mass spectrometry is often used as a complementary technique to BioID experiments, and the data presented here complements another project. To infer processes involving Ku70, we used AP-MS to identify candidate proteins that may interact with Ku70 and compared these ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-03 | PXD010930 | Pride
Ku70 Ap-ms Hek293 
ProteomicsPATCH labeling in the BSA through red light
For the liquid chromatography-mass spectrometry (LC-MS) analysis, the 500 μM AP was used to label BSA in the reaction, followed by clicking chemical conjugation with 0.1 mM azide-PEG3-biotin under 0.5 mM CuCl(2), 2 Mm Tris (3-hydroxypropyltriazolylmethyl) amine (THPTA, Sigma-Aldrich) and 5 mM ascorb...
ORGANISM(S): Bos taurus (Bovine) 
2025-07-30 | PXD057016 | Pride
Pcn bsa 
GenomicsGenome-wide maps of apurinic sites (AP-sites) and 8-oxoG derived secondary AP-sites
We developed a novel method, AP-seq, capable of mapping apurinic sites and 8-oxo-7,8-dihydroguanine bases at approximately 250bp resolution on a genome-wide scale. We directly demonstrate that the accumulation rate of apurinic sites varies widely across the genome, with hot spots acquiring many time...
ORGANISM(S): Homo sapiens 
2018-10-22 | GSE121005 | GEO
ProteomicsIdentification of MARCH2 E3 ligase-substrates using proximity-dependent biotin labeling method
MARCH2 is known to be involved in intracellular vesicular trafficking. To identify its substrates, we have recently developed a method based on proximity-dependent biotin labelling. In this protocol, the MARCH2 ubiquitin ligase of interest is expressed as a fusion to Escherichia coli biotin ligase ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-06 | PXD013601 | Pride
March2 Secretory proteins E3 ligase 
TranscriptomicsGlobal gene transcription analysis of Anaplasma phagocytophilum in tick and human cells using tiling microarrays
A whole genome tiling microarray based on the published sequence of the Anaplasma phagocytophilum (Ap) strain Hz genome was used to measure transcriptional activity of Ap grown to late stage in three cell lines representing the diversity of host cells naturally infected by Ap: two human cell lines, ...
ORGANISM(S): Anaplasma phagocytophilum HZ 
2008-08-04 | E-GEOD-11487 | biostudies-arrayexpress
TranscriptomicsTfap2a dependnt cha
Neo/null loss of Tfap2a in E10.5 mouse facial prominences triplicate run comparing tissue dissected from the nasal, maxillary and mandibular comparing AP-2 mutant and control embryos
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-60058 | biostudies-arrayexpress
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