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ProteomicsStructural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6
Certain Inhibitors of apoptosis (IAP) family members are sentinel proteins preventing untimely cell death by inhibiting caspases. Antagonists including second mitochondria-derived activator of caspase (SMAC) regulate IAPs, driving cell death. Baculoviral IAP repeat-containing protein 6 (BIRC6), a gi...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD039954 | Pride
Ap-ms Birc6 Structural biology Cell death Ubiquitomics Biochemistry 
ProteomicsCircBIRC6-2 inhibits transmissible gastroenteritis virus induced mitochondrial permeability transition pore opening by its encoding protein
Transmissible gastroenteritis virus (TGEV), a member of coronavirus, is the pathogen of TGE. We previously found 123 circular RNAs (circRNAs) were differential expression during activation of mitochondrial permeability transition in porcine intestinal epithelial cells-jejunum 2 cell line (IPEC-J2) ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-10-13 | PXD029055 | Pride
Lc-ms/ms Peptide analysis Interacting protein 
GenomicsDifferential transcriptional responses to BIRC6 depletion between BIRC6-dependent and -nondependent cells
Differential transcriptional responses to BIRC6 depletion between BIRC6-dependent and -nondependent cells
PRJNA914287 | ENA
TranscriptomicsDifferential transcriptional responses to BIRC6 depletion between BIRC6-dependent and -nondependent cells
To investigate the mechanism underlying the differing responses of cancer cells to BIRC6 depletion, we knocked out BIRC6 in a series of BIRC6-dependent and -nondependent cell lines. We subsequently profiled the effect of BIRC6 depletion on gene expression using RNA-sequencing.
ORGANISM(S): Homo sapiens 
2022-12-21 | GSE221430 | GEO
UnknownBIRC6 mediates imatinib resistance independently of Mcl-1.
Not available
S-EPMC5433768 | biostudies-literature
UnknownOverexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer.
Not available
S-EPMC4416929 | biostudies-literature
UnknownMolecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy.
Not available
S-EPMC10827748 | biostudies-literature
UnknownBIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque.
Not available
S-EPMC7763522 | biostudies-literature
TranscriptomicsBIRC6-targeting as potential therapy for advanced, enzalutamide-resistant prostate cancer
New transplantable patient-derived xenograft (PDX) CRPC model with intrinsic ENZ-Resistance were used to access therapeutic efficacy of BIRC6 targeting antisense oligonucleotide (ASO-6w2). Molecular pathways associated with the inhibitory effect of ASO-6w2 vs control Scrb ASO were examined by gene e...
ORGANISM(S): Homo sapiens 
2016-02-04 | GSE77516 | GEO
UnknownNegative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.
Not available
S-EPMC6863627 | biostudies-literature
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