Sort   by:  
 Page size 
ProteomicsMitochondrial stress in GLA mutants Zebrafish is independent of globotriaosylceramide accumulation
Fabry disease (FD) is a hereditary lysosomal storage disorder caused by mutations in GLA gene resulting in reduction or lack of α-galactosidase A activity. In humans, enzymatic deficiency leads to accumulation of globotriaosylceramide (Gb3) and other glycosphingolipids in lysosomes. Current therapie...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-10-24 | PXD035409 | Pride
Alpha-galactosidase a/ fabry disease/ lysosome/ mitochondrial activity/ proteomic approach 
ProteomicsBortezomib abrogates temozolomide-induced autophagic flux and kills glioblastoma cells through an ATG5 and ATG7 dependent pathway
Glioblastoma (GBM) carries a dismal prognosis largely due to acquired resistance to the standard treatment, which incorporates the chemotherapy temozolomide (TMZ). Inhibiting the proteasomal pathway is an emerging strategy, where combination treatments are under clinical investigation. We hypothesiz...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD021828 | Pride
Bortezomib abrogates temozolomide-induced autophagic flux and kills glioblastoma cells through an atg5 and atg7 dependent pathway 
ProteomicsProteomic analysis of peripheral blood mononuclear cells isolated from patients with pulmonary tuberculosis: a pilot study from Zanzibar, Tanzania
This study aimed at exploring the proteomic profile of PBMCs to predict response to treatment in pulmonary tuberculosis (PTB). This was a pilot study conducted among 8 adult patients from Zanzibar, Tanzania with confirmed PTB. Blood samples were collected at baseline, at 2 months of treatment, and a...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD029634 | Pride
Biomarkers  peripheral blood mononuclear cells  proteomics  pulmonary tuberculosis  treatment response. 
ProteomicsEarly response evaluation by single cell signaling profiling in acute myeloid leukemia
Background: A fundamental hallmark of cancer cells is their ability to sustain proliferative signaling and cell survival, reflected in a cellular chemotherapy response that is poorly understood. We questioned whether chemotherapy modulated phospho-signaling at 4 and 24 h in vivo could provide inform...
ORGANISM(S): Homo sapiens (Human) 
2022-10-26 | PXD031916 | Pride
Aml Erk Single cell 
UnknownBacterial Community Profiling of Tropical Freshwaters in Bangladesh.
Not available
S-EPMC6554655 | biostudies-literature
TranscriptomicsComparison of constitutional and replication stress-induced genome structural variation by SNP array and mate-pair sequencing
Copy number variants (CNVs) are a major source of genetic variation in human health and disease. Previous studies have suggested replication stress, such as that caused by the polymerase inhibitor aphidicolin, as a causative factor in CNV formation, but existing data are technically limited in the ...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-26121 | biostudies-arrayexpress
UnknownN-terminal pro-B-type natriuretic peptide levels vary by ethnicity and are associated with insulin sensitivity after gestational diabetes mellitus.
Not available
S-EPMC11298077 | biostudies-literature
Sort   by:  
 Page size