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ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD003213 | Pride
Mathematical modelling Rhoa Cell motility Rac1 Bistable switches Pak inhibition 
UnknownCell cycle oscillations driven by two interlinked bistable switches.
Not available
S-EPMC10208103 | biostudies-literature
ModelsDeBoeck2021 - Modular approach to modeling the cell cycle, 5 ODE model with 3 bistable switches
Model of the mammalian cell cycle as a chain of bistable switches. There are three bistable responses: response of E2F to Cyclin D, of Cdk1 to Cyclin B and of APC/C to Cdk1 activity. The model for the given parameters admits a complex limit cycle characterized by transitions through the bistable s...
2024-09-02 | BIOMD0000001080 | BioModels
UnknownOrigin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling.
Not available
S-EPMC10074143 | biostudies-literature
UnknownBrain activity dynamics in human parietal regions during spontaneous switches in bistable perception.
Not available
S-EPMC4306523 | biostudies-literature
UnknownConstruction of an in vitro bistable circuit from synthetic transcriptional switches.
Not available
S-EPMC1762086 | biostudies-literature
UnknownProtocol for potential energy-based bifurcation analysis, parameter searching, and phase diagram analysis of noncanonical bistable switches.
Not available
S-EPMC10751549 | biostudies-literature
UnknownTwo Bistable Switches Govern M Phase Entry.
Not available
S-EPMC5196020 | biostudies-literature
UnknownControl of tissue homeostasis, tumorigenesis, and degeneration by coupled bidirectional bistable switches.
Not available
S-EPMC8641876 | biostudies-literature
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