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ProteomicsThe Greatwall kinase safeguards the genome integrity by balancing the kinome activity in mitosis.
Mastl is commonly overexpressed in cancer, appearing as an alternative therapeutic anticancer target. Loss of Mastl induces multiple chromosomal mitotic errors that lead to the accumulation of micronuclei and multilobulated cells with polyploidy. Our detailed analyses display that loss of Mastl quic...
ORGANISM(S): Mus Musculus (mouse) 
2020-10-15 | PXD019297 | JPOST Repository
ProteomicsUntargeted LC-MS/MS proteomics on supernatant of endothelial cells exposed to Myeloperoxidase-oxidized LDLs (Mox-LDLs)
Myeloperoxidase-oxidized LDLs (Mox-LDLs) trigger endothelial cells and participate in atherosclerosis. However, the mechanisms behind Mox-LDLs stimulation are not fully understood. Therefore, we used an untargeted proteomics approach to analyze human umbilical vein endothelial cells (HUVECs) after s...
ORGANISM(S): Homo sapiens (Human) 
2025-10-09 | PXD061942 | Pride
Supernatant Endothelial cell Dia Cell lysate Lc-ms/ms 
ProteomicsUntargeted LC-MS/MS proteomics on cell lysate of endothelial cells exposed to Myeloperoxidase-oxidized LDLs (Mox-LDLs)
Myeloperoxidase-oxidized LDLs (Mox-LDLs) trigger endothelial cells and participate in atherosclerosis. However, the mechanisms behind Mox-LDLs stimulation are not fully understood. Therefore, we used an untargeted proteomics approach to analyze human umbilical vein endothelial cells (HUVECs) after s...
ORGANISM(S): Homo sapiens (Human) 
2025-10-09 | PXD061940 | Pride
Supernatant Endothelial cell Dia Cell lysate Lc-ms/ms 
ProteomicsProteomic signatures of the chemotherapy-induced damage in the human ovary
Although the mechanisms underlying chemotherapy-induced damage to germ cells are being increasingly deciphered, its impact on the ovarian microenvironment remains largely unexplored. The ovarian stroma is equally exposed to chemotherapy, and since its cells and components are in active communication...
ORGANISM(S): Homo sapiens (Human) 
2025-11-07 | PXD064815 | Pride
Ovarian tissue Gonadotoxicity Ovarian microenvironment Chemotherapy Stromal cells Fertility preservation 
ProteomicsK562 Chemical arrest cell cycle phase fractions 2D-MS-CETSA
K562 cells were synchronized by double thymidine block(DTB) based chemical arrest scheme into G1/S, S and Prometaphase(PM) fractions. Three biological replicates were collected on different days, and assembled into a 2D-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC,54ºC ...
ORGANISM(S): Homo Sapiens (human) 
2018-05-08 | PXD009146 | JPOST Repository
ProteomicsK562 Elutriation cell cycle phase fractions 2D-MS-CETSA
K562 cells were synchronized by cell size difference based Elutriation scheme into G1, S and G2 fractions. Three biological replicates were collected on different days, and assembled into a 2D-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC,54ºC and 57ºC), (Figure 1A, Meth...
ORGANISM(S): Homo Sapiens (human) 
2018-05-08 | PXD009171 | JPOST Repository
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