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GenomicsBivalent Chromatin Marks Developmental Regulatory Genes in the Mouse Embryonic Germline in Vivo
We developed a ChIP protocol for the analysis of histone marks using less than 10,000 cells per IP, and used it to investigate the chromatin state of E11.5 mouse primordial germ cells (PGCs). A genome-wide ChIP-Seq analysis of E11.5 PGCs revealed a distribution of H3K4me3/H3K27me3 bivalent domains h...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-46396 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20242 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20236 | biostudies-arrayexpress
UnknownA low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin.
Not available
S-EPMC10858499 | biostudies-literature
UnknownGeneration of bivalent chromatin domains during cell fate decisions.
Not available
S-EPMC3131236 | biostudies-literature
TranscriptomicsUnique cell cycle-dependent variations in the pluripotent epigenetic landscape define novel cohorts of temporal expressed bivalent genes during hESCs differentiation
By mapping the genomic enrichments  of H3K4me3 and H3K27me3 modifications in pure populations of hESCs during the G2, mitotic and G1 phases of the cell cycle, we characterize cell cycle-dependent variations in the epigenetic landscape of bivalent genes, altering the current view of mitotic inherita...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-55502 | biostudies-arrayexpress
GenomicsSubnuclear genome compartmentalization controls bivalent chromatin activity
Subnuclear genome compartmentalization controls bivalent chromatin activity
PRJNA1144500 | ENA
TranscriptomicsGenome wide analysis of bivalent domains in two HUES cell lines
Human embryonic stem (HUES) cells are derived from early individual embryos with unique genetic properties. However, how their epigenetic status might affect their potential to differentiate toward specific lineages remains a puzzling question. Using ChIP-on-chip, the status of bivalent domains on...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-59328 | biostudies-arrayexpress
GenomicsA novel bivalent chromatin state exists at enhancers
We assess global chromatin accessibility following 5-Aza-CdR treatment of HCT116 cells Simultaneous genome-wide mapping of DNA methylation and nucleosome occupancy of HCT116 cells
ORGANISM(S): Homo sapiens 
2016-06-02 | E-GEOD-68046 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state in E12.5 mouse forelimbs
The chromatin state in developing body parts provides a zip code to cellular populations that direct their cell fates. We used antibodies for H3K4me3, H3K27me3 and Pol2, to identify the chromatin state signature of the mouse forelimb during mid-gestation, at embryonic day 12. The families of genes m...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-49010 | biostudies-arrayexpress
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