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GenomicsGenome-wide maps of chromatin state in Germinal Center B cells.
Protection against deadly pathogens requires the production of high-affinity antibodies by B cells. High-affinity antibody-forming cells are generated in germinal centers (GC) as a result of a developmental program that is commonly altered in B cell malignancies. Identification of regulators of the ...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-50912 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of differentially expressed regions between C57BL/6 and BALB/c in bone marrow derived macrophages
DNA-methylation is a vital epigenetic mark that participates in establishing and maintaining chromatin structures and in regulating gene transcription during mammalian development and cellular differentiation. Inter-individual differences in methylation patterns may represent a major source of pheno...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-14463 | biostudies-arrayexpress
MetabolomicsTwo UGT84A Family Glycosyltransferases Regulate Phenol, Flavonoid, and Tannin Metabolism in Juglans regia (English Walnut)
We showed previously that gallic acid is produced in walnut from 3-dehydroshikimate by a shikimate dehydrogenase (JrSkDH). This study focuses on the next step in the hydrolysable tannin pathway, the formation of 1-O-galloyl-β-D-glucose from the phenolic gallic acid and UDP glucose by a glycos...
2022-10-11 | MTBLS2042 | MetaboLights
MetabolomicsComputational Ranking of Yerba Mate Small Molecules Based on Their Predicted Contribution to Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus
The aqueous extract of yerba mate, a South American tea beverage made from Ilex paraguariensis leaves, has demonstrated bactericidal and inhibitory activity against bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The gas chromatography-mass spectrometry (GC-MS) ana...
2015-03-19 | MTBLS170 | MetaboLights
TranscriptomicsDiscovery and validation of a novel expression signature for recurrence in high-risk bladder cancer post-cystectomy
Purpose: Selecting muscle-invasive bladder cancer patients for adjuvant therapy is currently based on clinical variables with limited power. We hypothesized that genomic-based signatures can outperform clinical models to identify patients at higher risk. Method:Transcriptome-wide expression profiles...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-57933 | biostudies-arrayexpress
TranscriptomicsGene responses in mouse brain to long-term exposure to microgravity
The spaceflight experiment was carried out using male C57BL/10J mice (8 weeks old at launch). Wild type mice (n=3) were launched by Space Shuttle Discovery and housed on the International Space Station (ISS) for 91 days. They returned to the Earth by Space Shuttle Atlantis. But only one mouse ret...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-32077 | biostudies-arrayexpress
UnknownEffect of Upregulation of Transcription Factor TFDP1 Binding Promoter Activity Due to RBP4 g.36491960G>C Mutation on the Proliferation of Goat Granulosa Cells
Not available
S-EPMC9321149 | biostudies-literature
GenomicsCpG islands and GC content dictate nucleosome depletion in a transcription independent manner at mammalian promoters
This SuperSeries is composed of the following subset Series: GSE38560: CpG islands and GC content dictate nucleosome depletion in a transcription independent manner at mammalian promoters (RNA-seq) GSE38561: CpG islands and GC content dictate nucleosome depletion in a transcription independent manne...
ORGANISM(S): Mus musculus 
2012-06-11 | E-GEOD-38577 | biostudies-arrayexpress
MetabolomicsComparative metabolomics analysis reveals high-altitude adaptations in a toad-headed viviparous lizard, Phrynocephalus vlangalii
Extreme environmental conditions at high altitude, such as hypobaric hypoxia, low temperature, and strong UV radiation, pose a great challenge to the survival of animals. Although the mechanisms of adaptation to high-altitude environments have attracted much attention for native plateau species, the...
2024-01-16 | MTBLS6900 | MetaboLights
GenomicsCpG islands and GC content dictate nucleosome depletion in a transcription independent manner at mammalian promoters (MNase-seq)
One clear hallmark of mammalian promoters is the presence of CpG islands (CGIs) at more than two thirds of genes whereas TATA boxes are only present at a minority of promoters. Using genome-wide approaches, we show that GC content and CGIs are major promoter elements in mammalian cells, able to gove...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-38563 | biostudies-arrayexpress
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