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TranscriptomicsTranscription profiling of primary rat hippocampal culture cells overexpressing an activated form of calcineurin
Micorarray analysis was performed on RNA samples from hippocampal cultures infected with either Ad-aCaN or Ad-LacZ or uninfected. Each sample was applied to its own GeneChip (Rat RG-U34A; n=7-9 chips/group). Chips were then processed and scanned using Agilent Affymetrix GeneArray Scanner. MAS5 was u...
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-GEOD-1978 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid-Dependent Hippocampal Transcriptome in Male Rats: Pathway-Specific Alterations with Aging
Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the longstanding hypothesis that chronic GC exposure promotes brain aging/Alzheimer's disease. Here, we adr...
ORGANISM(S): Rattus norvegicus 
2013-07-22 | E-GEOD-37618 | biostudies-arrayexpress
TranscriptomicsThe Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging
Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate pote...
ORGANISM(S): Rattus norvegicus 
2012-07-16 | E-GEOD-34424 | biostudies-arrayexpress
TranscriptomicsMicroarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer’s disease
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that threatens to reach epidemic proportions as our population ages. Although much research has examined molecular pathways associated with AD, relatively few studies have focused on critical early stages. Our prior microarray stud...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-28146 | biostudies-arrayexpress
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rodent hippocampal CA1 tissue during aging and cognitive decline
Recent microarray studies in the hippocampus of rodents or Alzheimer’s disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairm...
ORGANISM(S): Rattus norvegicus 
2009-01-25 | E-GEOD-9990 | biostudies-arrayexpress
TranscriptomicsGene expression by myriocin treatment
Studies of aging and longevity are revealing how diseases that shorten life can be controlled to improve the quality of life and lifespan itself. Two strategies under intense study to accomplish this goal are rapamycin treatment and calorie restriction. New strategies are being discovered includin...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-22 | E-GEOD-41362 | biostudies-arrayexpress
TranscriptomicsDeep Sleep and Parietal Cortex Gene Expression Changes are Related to Cognitive Deficits with Age
Background: Age-related cognitive deficits negatively affect quality of life and can presage serious neurodegenerative disorders. Despite sleep disruption’s well-recognized negative influence on cognition, and its prevalence with age, surprisingly few studies have tested sleep’s relationship to cogn...
ORGANISM(S): Rattus norvegicus 
2011-04-21 | E-GEOD-24515 | biostudies-arrayexpress
TranscriptomicsA role for nuclear factor interleukin-3 (NFIL3), a critical transcriptional repressor, in down-regulation of periovulatory gene expression
The LH surge triggers dramatic transcriptional changes in genes associated with ovulation and luteinization. The present study investigated the spatiotemporal expression of nuclear factor interleukin-3 (NFIL3), a transcriptional regulator of the bZIP transcription factor superfamily, and its potenti...
ORGANISM(S): Rattus norvegicus 
2011-01-20 | E-GEOD-26730 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brains from cognitively impaired and unimpaired old rats and young rats at zero or 21 days post water maze training, and untrained individuals
Although immediate early genes (IEGs) such as Bdnf, Arc and Egr1, have been implicated in plasticity, the larger pathways related to memory and memory disorders are not well understood. Here, we combined statistical Affymetrix microarray and behavioral analyses to identify key genes and pathways ass...
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-5666 | biostudies-arrayexpress
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