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MetabolomicsUntargeted LC-HRMS Based-Plasma Metabolomics Reveals 3-O-Methyldopa as a New Biomarker of Poor Prognosis in High-Risk Neuroblastoma
Neuroblastoma (NB) is the most common extracranial malignant tumor in children. Although the survival rate of NB has improved over the years, the outcome of NB still remains poor for over 30% of cases. A more accurate risk stratification remains a key point in the study of NB and the availability of...
2023-07-14 | MTBLS4294 | MetaboLights
UnknownDead and buried? Variation in post-mortem histories revealed through histotaphonomic characterisation of human bone from megalithic graves in Sweden.
Not available
S-EPMC6169911 | biostudies-literature
TranscriptomicsTranscription profiling of Drosophila embryos at stages 11 and 12 to identify genes downstream of Hox
Identification of Hox gene downstream genes at embryonic stages 11 and 12

Functional diversification of body parts is dependent on the formation of specialized structures along the various body axes. In animals, region-specific morphogenesis along the anterior-posterior axis is controlled by ...
ORGANISM(S): Drosophila melanogaster 
2008-04-09 | E-MEXP-879 | biostudies-arrayexpress
MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis for resting cells (B.uniformis;C.saccharolyticum assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1757 | MetaboLights
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis (FIA-MS) (C.saccharolyticum;E.coli;L.plantarum;L.lactis;S.salivarius assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1791 | MetaboLights
MetabolomicsBioaccumulation of therapeutic drugs by human gut bacteria: duloxetine accumulation at different concentrations (L.saccharolytica;E.coli assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1319 | MetaboLights
ProteomicsAltered brain pathways following Chikungunya virus infection
A kinetic analysis of host proteome modifications in the brain of CHIKV-infected mice sampled before and after the onset of clinical symptoms was performed. The combination of 2D-DIGE and iTRAQ proteomic approaches, followed by mass spectrometry protein identification, revealed 177 significantly dif...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-07 | PXD000736 | Pride
Brain Pathways modified Mouse Alphavirus Chikungunya virus Infection Itraq Pathogenesis 2d-dige 
ProteomicsLife-Death Trade-offs: HSV-1 ICP27 as a Cellular Context-Dependent Regulator of Intrinsic Apoptosis
Herpes simplex virus type 1 (HSV-1) infection represents an established model for studying virus-host interactions, given its ability to modulate cell fate and achieve long-term persistence. Among the immediate early genes, the multifunctional regulatory protein ICP27, encoded by the UL54 gene, play...
ORGANISM(S): Homo sapiens (Human) 
2026-06-16 | PXD071831 | Pride
Hsv-1 Icp27 Htert rpe-1 Sh-sy5y Apoptosis 
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