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ProteomicsIP-MS analysis
It has recently been shown that HSV-1 infection induces widespread defect in host gene transcription termination while viral genes are unaffected. However, The underlying mechanism remain poorly understood. According to our sequencing data, ICP27 as an immediate early protein of HSV-1 was involved i...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012837 | Pride
Icp27 Immunoprecipitation Hsv 3’ end processing 
GenomicsHerpes Simplex Virus blocks host transcription termination via the bimodal activities of ICP27.
Herpes Simplex Virus blocks host transcription termination via the bimodal activities of ICP27.
PRJNA528792 | ENA
ProteomicsLife-Death Trade-offs: HSV-1 ICP27 as a Cellular Context-Dependent Regulator of Intrinsic Apoptosis
Herpes simplex virus type 1 (HSV-1) infection represents an established model for studying virus-host interactions, given its ability to modulate cell fate and achieve long-term persistence. Among the immediate early genes, the multifunctional regulatory protein ICP27, encoded by the UL54 gene, play...
ORGANISM(S): Homo sapiens (Human) 
2026-06-16 | PXD071831 | Pride
Hsv-1 Icp27 Htert rpe-1 Sh-sy5y Apoptosis 
TranscriptomicsHerpes Simplex Virus blocks host transcription termination via the bimodal activities of ICP27.
Infection by viruses, including Herpes Simplex virus-1 (HSV-1), and cellular stresses cause widespread disruption of transcription termination (DoTT) of RNA polymerase II (RNAPII). The underlying mechanisms, however, remain unclear. Here we demonstrate that, in HSV-1-infected cells, the viral immedi...
ORGANISM(S): Homo sapiens 
2019-12-15 | GSE128753 | GEO
UnknownHerpes simplex virus 1 regulatory protein ICP27 undergoes a head-to-tail intramolecular interaction.
Not available
S-EPMC2863791 | biostudies-literature
UnknownHerpesvirus protein ICP27 switches PML isoform by altering mRNA splicing.
Not available
S-EPMC2770646 | biostudies-literature
GenomicsAberrant RNA polymerase Initiation and Processivity on the Genome of a Herpes Simplex Virus 1 Mutant Lacking ICP27
Aberrant RNA polymerase Initiation and Processivity on the Genome of a Herpes Simplex Virus 1 Mutant Lacking ICP27
PRJNA1013976 | ENA
GenomicsSubcellular RNA fractions of primary human fibroblasts infected with the HSV-1 delta-ICP27 mutant
Subcellular RNA fractions of primary human fibroblasts infected with the HSV-1 delta-ICP27 mutant
PRJNA529207 | ENA
UnknownHerpes simplex virus ICP27 regulates alternative pre-mRNA polyadenylation and splicing in a sequence-dependent manner.
Not available
S-EPMC5087043 | biostudies-literature
UnknownHerpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways.
Not available
S-EPMC3320978 | biostudies-literature
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