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MetabolomicsEffects of nicotine on SH-SY5Y cells: an NMR-based metabolomic study

Nicotine is a naturally occurring alkaloid primarily found in Nicotiana tabacum. This phytochemical is well known for its addictive properties, and its consumption—particularly through tobacco smoking—is strongly associated with an increased risk of malignancies, metabolic dysfunctions, and cardi...

2026-06-26 | MTBLS12848 | MetaboLights
TranscriptomicsTranscription profiling of neuronal differentiation in two subtypes of SH-SY5Y
Background: SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signaling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehens...
ORGANISM(S): Homo sapiens 
2009-09-04 | E-GEOD-9169 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Pea3, Erm and Er81 overexpression in SH-SY5Y cell line
Investigation of whole genome gene expression level changes in SH-SY5Y cells transfected pCDNA3-Pea3, pCDNA3-Erm, and pCDNA3-Er81 cells compared to pCDNA3 transfected cells as a control.
ORGANISM(S): Homo sapiens 
2020-10-28 | E-MTAB-8473 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human human neuroblastoma SH-SY5Y cells identifies molecular effectors of unconjugated bilirubin
This SuperSeries is composed of the following subset Series:; GSE16656: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblatoma SH-SY5Y cells: 24h; GSE16766: Transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neurobl...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-16768 | biostudies-arrayexpress
TranscriptomicsProfiling neuroblastoma SH-SY5Y with Paraquat treatment
Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared w...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21305 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma SH-SY5Y cells: 4h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-16767 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblatoma SH-SY5Y cells: 24h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-11-29 | E-GEOD-16656 | biostudies-arrayexpress
ProteomicsLC-MS/MS analysis of B12 treated SH-SY5Y cells
B12 is a compound that has neuroprotective effects. We investigated the protein expression profile associated with the neuroprotective effects of B12 on human neuronal cells SH-SY5Y using label-free quantitative proteomics.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-12-29 | MSV000079437 | MassIVE
TranscriptomicsTranscription profiling of human human neuroblastoma SH-SY5Y cells: 1h identifies molecular effectors of unconjugated bilirubin
The deposition of unconjugated bilirubin (UCB) in selected regions of the brain results in irreversible neuronal damage, or Bilirubin Encephalopathy (BE). Although UCB impairs a large number of cellular functions, the basic mechanisms of neurotoxicity have not yet been fully clarified. While cells c...
ORGANISM(S): Homo sapiens 
2009-11-29 | E-GEOD-16766 | biostudies-arrayexpress
TranscriptomicsmicroRNA array of SH-SY5Y cells
This experiment captures expression over 60,000 well-annotated RefSeq human transcripts over RNA samples from SH-SY5Y neuroblastoma cells transfected with human and non-human primate microRNA mimic variants of miR-299-3p, miR-503-3p, miR-508-3p and miR-541-3p, as well as a RNA duplex negative contro...
ORGANISM(S): Homo sapiens 
2016-04-03 | E-MTAB-3617 | biostudies-arrayexpress
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