Sort   by:  
 Page size 
GenomicsGenome-wide maps of RAP1 binding sites.
By performing chromatin immunoprecipitation coupled with ultra-high-throughput sequencing (ChIP-seq), we find that RAP1 binds to telomeres as well as to extra-telomeric sites through the (TTAGGG)2 consensus motif. Extra-telomeric RAP1 binding sites are particularly abundant at subtelomeric regions, ...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-20867 | biostudies-arrayexpress
TranscriptomicsRoles of mammalian Rap1 in TERT recruitment to chromatin, subtelomeric gene silencing and transcriptional regulation
Repressor-activator protein 1 (scRap1) is the major binding activity at Saccharomyces cerevisiae telomeres, with roles in telomere length regulation and establishment of subtelomeric silencing by recruiting the Sir proteins. scRap1 also acts as a transcription factor controlling the expression of ri...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-19011 | biostudies-arrayexpress
TranscriptomicsPrimary murine embryonic fibroblasts (MEFs): Cdk7 wild type versus Cdk7 KO
Transcriptional profiling of primary Cdk7lox/lox MEFs comparing Adeno-Cre vs Adeno-GFP infected controls. Samples were obtained 7 days after the Adeno-Cre mediated elimination of Cdk7. Goal was to determine the effects of Cdk7 elimination on RNA polII-mediated transcription. Two-condition experiment...
ORGANISM(S): Mus musculus 
2012-04-17 | E-GEOD-36050 | biostudies-arrayexpress
UnknownThe mTOR pathway is necessary for survival of mice with short telomeres.
Not available
S-EPMC7054554 | biostudies-literature
TranscriptomicsProtective response to Brucella infection
Brucella ovis causes an important disease characterized by decreased fertility in rams, sporadic abortions in ewes and increased lamb mortality. The live attenuated B. melitensis Rev.1 vaccine is considered the best vaccine available against this infection. However, this vaccine shows variable prot...
ORGANISM(S): Ovis aries 
2010-06-25 | E-GEOD-13202 | biostudies-arrayexpress
UnknownFive-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy: A Randomized Clinical Trial With Open-Label Extension.
Not available
S-EPMC11894486 | biostudies-literature
ProteomicsAutoantibody profile timecourse of UNK
We have determined the whole genome sequence of an individual at high accuracy and performed an integrated analysis of omics profiles over a 1.5 year period that included healthy and two virally infected states. Omics profiling of transcriptomes, proteomes, cytokines, metabolomes and autoantibodyome...
ORGANISM(S): Homo sapiens 
2012-03-16 | E-GEOD-32691 | biostudies-arrayexpress
TranscriptomicsPersonal Omics Profiling Reveals Dynamic Molecular Phenotypes and Actionable Medical Risks
We have determined the whole genome sequence of an individual at high accuracy and performed an integrated analysis of omics profiles over a 1.5 year period that included healthy and two virally infected states. Omics profiling of transcriptomes, proteomes, cytokines, metabolomes and autoantibodyome...
ORGANISM(S): Homo sapiens 
2012-03-16 | E-GEOD-32874 | biostudies-arrayexpress
UnknownFirst-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer.
Not available
S-EPMC6487310 | biostudies-literature
UnknownMultilevel mortality risk factors among pediatric hematology-oncology patients with deterioration.
Not available
S-EPMC11975202 | biostudies-literature
Sort   by:  
 Page size