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TranscriptomicsBlastomere-specific transcriptome sequencing reveals a determinant of anterior specification in C. elegans
We sequenced amplified mRNA from 20 pooled AB and 20 pooled P1 blastomeres hand isolated from 2-cell stage C. elegans embryos three replicates each. Transcriptome profiles of each blastomere at the 2-cell stage of the C. elegans early embryo.
ORGANISM(S): Caenorhabditis elegans 
2015-03-05 | E-GEOD-59943 | biostudies-arrayexpress
TranscriptomicsComparative analysis of gene expression profiles between four kinds of blastomere at 8-cell stage embryos.
The establishment of body axes and specification of early embryonic cells depend on maternally supplied transcripts and/or proteins, several of which are localized at specific regions of fertilized eggs and early embryos. The ascidian is known to exhibit a mosaic mode of development, and this mode ...
ORGANISM(S): Ciona intestinalis 
2010-06-19 | E-GEOD-15637 | biostudies-arrayexpress
TranscriptomicsHuman embryonic stem cells derived from embryos at different stages of development share similar transcription profiles
We have derived hESC from biopsied blastomeres of cleavage stage embryos under virtually the same conditions we used for the derivation of hESC lines from inner cell mass of blastocyst stage embryos. Blastomere-derived hESC lines exhibited all the standard characteristics of hESC including undiffer...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-29625 | biostudies-arrayexpress
TranscriptomicsEthanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects
Gene expression was measured using microarrays in 8 hour postfertilization embryos, comparing control versus ethanol-treated (2 to 8 hours postfertilization) embryos. This experiment was performed to determine the gene expression changes that occur in response to ethanol treatment as a model of feta...
ORGANISM(S): Danio rerio 
2014-07-09 | E-GEOD-48380 | biostudies-arrayexpress
TranscriptomicsCell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing
It remains an open question when and how the first cell fate decision is made in mammals. Using deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible interblastomere differences among ten 2-cell and five 4-cell mouse embryos. Inter-blastomere gene expression differenc...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-57249 | biostudies-arrayexpress
GenomicsMouse embryo transcriptomes after two-cell blastomere separation
Mouse embryo transcriptomes after two-cell blastomere separation
PRJNA1460311 | ENA
ProteomicsFilter aided, single tip (FAST) method for high throughput, ultrasensitive proteomics sample preparation reveals proteome asymmetry in Xenopus embryos
We report a filter aided, single tip (FAST) method for ultrasensitive proteomic sample preparation. To minimize sample loss and contamination, the method reduces the surface area of the filter to ~0.1 mm2, the total volume of reagents to < 10 μL, and the number of sample transfer steps to two. 25,88...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2022-07-12 | PXD015175 | Pride
Single blastomere Sample preparation Ultrasensitive proteomics 
UnknownThe effect of blastomere biopsy on preimplantation mouse embryo development and global gene expression.
Not available
S-EPMC2683241 | biostudies-literature
UnknownThe impact of blastomere loss on pregnancy and neonatal outcomes of vitrified-warmed Day3 embryos in single embryo transfer cycles.
Not available
S-EPMC9116052 | biostudies-literature
UnknownCleavage modification did not alter blastomere fates during bryozoan evolution.
Not available
S-EPMC5408385 | biostudies-literature
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