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TranscriptomicsTranscription profiling by array of breast cancer distant metastasis based on outcome over time and identification of pathway activities of late relapse
Previous reports have described the use of microarrays to assess the molecular classification of human breast cancers and defined new subgroups based on gene expression that are relevant to patient management through their ability to predict metastatic relapse and survival relapse. However, differen...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-MTAB-949 | biostudies-arrayexpress
TranscriptomicsMedicago truncatula roots. Nodulation vs. Arsenic
Legumes, in interaction with resistant rhizobia, combined both moderate tolerance and accumulation of metal(loids) in roots, with the ability to grow without nitrogen supply (Pajuelo et al., 2011). This quality has attracted attention for phytostabilisation of polluted soils (Reichman, 2007). Physio...
ORGANISM(S): Medicago truncatula 
2014-12-08 | E-MTAB-1723 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Myb-MuvB/dREAM
Myb-MuvB (MMB)/dREAM is a nine subunit complex first described in Drosophila as a repressor of transcription, dependent upon E2F2 and the RBFs. Myb, an integral member of MMB, curiously plays no role in the silencing of the test genes previously analyzed. Moreover, Myb plays an activating role in DN...
ORGANISM(S): Drosophila melanogaster 
2008-06-16 | E-GEOD-8751 | biostudies-arrayexpress
TranscriptomicsGenome position and gene amplification - expressional profiling of methotrexate resistant colonies
We investigated the influence of genome position on propensity to amplify. First, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. We observed site specific d...
ORGANISM(S): Homo sapiens 
2007-10-08 | E-GEOD-6361 | biostudies-arrayexpress
TranscriptomicsInnate and adaptive immunity in zebrafish: time course (zebrafish)
The interaction between fungal pathogen and host innnate and adaptive immunity during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histolog...
ORGANISM(S): Danio rerio 
2014-11-03 | E-GEOD-51603 | biostudies-arrayexpress
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
TranscriptomicsA family of secreted pathogenesis-related proteins in Candida albicans
Analyzing culture supernatants of yeast and hyphal cells of Candida albicans by mass spectrometry, we found two close homologues of pathogenesis-related (PR-) 1 proteins, Rbe1p and Rbt4p, in the secretome of this human pathogen. By sequence homology, we assigned three yet not characterized open read...
ORGANISM(S): Candida albicans 
2013-03-25 | E-GEOD-28212 | biostudies-arrayexpress
OtherMixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency.
Data from ProteomeXchange, PXD ID: PXD002150. File: 14july14_saha_b_65.mzml. Published as part of Antiviral Res. 2015 Sep 3. pii: S0166-3542(15)00213-2 . From the Abstract: {{i}} ... We therefore utilized a combined analysis of effects of SAHA on the host transcriptome and proteome to dissect its m...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310023592 | GPMDB
Resource Reanalysis 
TranscriptomicsTranscription profiling of human Th cells induced to polarize to Th1 or Th2 direction in the presence or absence of TGFbeta
Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to ...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2770 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of mouse lung tissue exposed to two multiwalled carbon nanotubes (NRCWE-26 and NM-401)
Multi-walled carbon nanotubes (MWCNTs) are extensively produced and used in composite materials and electronic applications, thus increasing risk of worker and consumer exposure. MWCNTs are an inhomogeneous group of nanomaterials that exist in various lengths, shapes and with different metal composi...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-55286 | biostudies-arrayexpress
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