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MetabolomicsGluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglected tropical diseases caused by these parasites. Ho...
2018-12-10 | MTBLS706 | MetaboLights
MetabolomicsMapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC–MS
The metabolism of the parasite Trypanosoma brucei has been the focus of numerous studies since the 1940s. Recently it was shown, using metabolomics coupled with heavy-atom isotope labelled glucose, that the metabolism of the bloodstream form parasite is more complex than previously thought. The pres...
2019-06-24 | MTBLS624 | MetaboLights
TranscriptomicsWild-type Lister 427 Bloodstream-form polysome profiles with ZC3H32 knock-down
Ran from polysomes of Lister 427 bloodstream forms, wild-type and a cell line with a double knockout and inducible ZC3H32, grown without tetracycline.
ORGANISM(S): Trypanosoma brucei 
2017-11-24 | E-MTAB-4558 | biostudies-arrayexpress
ProteomicsBloodstream infection N-glycoproteomics
Here we have performed targeted quantitative N-glycoproteomics from plasma samples of patients with confirmed positive blood culture together with age and sex matched febrile controls with negative blood culture reports. Three hundred and sixty eight potential N-glycopeptides were quantified by mass...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD009048 | Pride
Sepsis Human plasma Bloodstream infection N-glycoproteomics 
ProteomicsQuantitative proteomics of bloodstream infection
We have performed LC-MS based plasma proteomics of twenty febrile patients coming in at Peijas Hospital, Helsinki University Hospital (Vantaa, Finland). At the same time, blood culture was performed to classify the patients to blood culture positive and negative for bloodstream infections. Blood cul...
ORGANISM(S): Homo sapiens (Human) 
2017-02-28 | PXD005022 | Pride
Mse Sepsis Bloodstream infection 
GenomicsBloodstream infection in leukemia
Bloodstream infection in leukemia
PRJNA477837 | ENA
TranscriptomicsRegulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host
The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly. However, trypanosomes also undergo development within the mammalian bloodstream as they progress from morphologically M-bM...
ORGANISM(S): Trypanosoma brucei brucei 
2013-12-16 | E-GEOD-46388 | biostudies-arrayexpress
GenomicsRNAi against DRBD18 in Trypanosoma brucei bloodstream forms
RNAi against DRBD18 in Trypanosoma brucei bloodstream forms
PRJEB41419 | ENA
TranscriptomicsBloodstream infection in leukemia
We examine the role of the gastrointestinal lymphatic tissue (GALT) in the formation of bloodstream infections in leukemia
ORGANISM(S): Mus musculus 
2018-06-26 | GSE116234 | GEO
GenomicsPUF3 RNAi in bloodstream-form of Trypanosoma brucei
PUF3 RNAi in bloodstream-form of Trypanosoma brucei
PRJEB33062 | ENA
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