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ProteomicsSUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells
Co-activator complexes regulate chromatin accessibility and transcription. SAGA (Spt-Ada-Gcn5 Acetyltransferase) is an evolutionary conserved multisubunit co-activator complex with modular organization. The core module of SAGA constitutes the structural heart, composed of a histone octamer like stru...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-07-26 | PXD026991 | Pride
Elisabeth scheer Didier devys Damien plassard Elisabeth lata bastian morlet And lászló tora Veronique fischer Stéphane d. vincent 
TranscriptomicsHigh-throughput sequencing of small RNAs in chicken somite embryos
High-throughput sequencing of small RNAs in chicken somite embryos Dissected tissue white leghorn chicken embryos was disaggregated and RNA extracted using the miRVana kit (Ambion). Small RNA fraction between 19 and 24 nt was isolated from 15% denaturing polyacrylamide gel and 15 micro gram was liga...
ORGANISM(S): Gallus gallus 
2009-04-27 | E-GEOD-15513 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of small RNAs in Medicago truncatula
Medicago truncatula endogenous small RNAs The dataset contains Medicago truncatula Gaertn. cv. Jemalong endogenous small RNA sequences in the range 18-28 nucleotides. High-throughput Solexa/Illumina sequencing was carried out at the Sainsbury Laboratory, Norwich, UK. Please see www.illumina.com for...
ORGANISM(S): Medicago truncatula 
2009-11-09 | E-GEOD-13761 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human intestinal organoids colonized with E. coli and other immature intestinal tissues
We performed RNA-seq to demonstrate that the epithelium of human pluripotent stem cell-derived human intestinal organoids is globally similar to the immature human epithelium and we utilize HIOs to investigate complex host-microbe interactions in this naive epithelium. RNA was isolated using the mir...
ORGANISM(S): Homo sapiens 
2017-09-01 | E-MTAB-5801 | biostudies-arrayexpress
UnknownUncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1.
Not available
S-EPMC7226996 | biostudies-literature
UnknownAn X-linked myopathy with postural muscle atrophy and generalized hypertrophy, termed XMPMA, is caused by mutations in FHL1.
Not available
S-EPMC2253986 | biostudies-literature
ProteomicsNuclear localization of glutaminyl-tRNA synthase QARS reveals its role in DNA damage repair in ovarian cancer
Uncovering novel mechanisms controlling DNA damage response (DDR) is essential to better understand the molecular features of high-grade serous ovarian cancers (HGSOC), which remain a clinical challenge. Here we demonstrate that the glutaminyl-tRNA-synthetase QARS is a new key player in DDR. We show...
ORGANISM(S): Homo sapiens (Human) 
2026-05-18 | PXD068960 | Pride
Qars Map kinases Dna damage response Ovarian cancer Homologous recombination 
UnknownThe clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.
Not available
S-EPMC4581915 | biostudies-literature
UnknownEfficacy of oseltamivir-zanamivir combination compared to each monotherapy for seasonal influenza: a randomized placebo-controlled trial.
Not available
S-EPMC2970549 | biostudies-literature
UnknownGenetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis.
Not available
S-EPMC10317892 | biostudies-literature
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