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ProteomicsNuclear localization of glutaminyl-tRNA synthase QARS reveals its role in DNA damage repair in ovarian cancer
Uncovering novel mechanisms controlling DNA damage response (DDR) is essential to better understand the molecular features of high-grade serous ovarian cancers (HGSOC), which remain a clinical challenge. Here we demonstrate that the glutaminyl-tRNA-synthetase QARS is a new key player in DDR. We show...
ORGANISM(S): Homo sapiens (Human) 
2026-05-18 | PXD068960 | Pride
Qars Map kinases Dna damage response Ovarian cancer Homologous recombination 
UnknownMutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.
Not available
S-EPMC3980424 | biostudies-literature
UnknownDefining and expanding the phenotype of QARS-associated developmental epileptic encephalopathy.
Not available
S-EPMC6927360 | biostudies-literature
UnknownSurficial N+ charge density indicating antibacterial capacity of quaternary ammonium resins in water environment.
Not available
S-EPMC7526928 | biostudies-literature
TranscriptomicsIdentification of miRNAs and their target genes in developing maize ears by deep sequencing
In plants, MicroRNAs (miRNAs) are a new class of endogenous small RNAs that play essential regulatory roles in plant growth, development and stress response. Extensive studies of miRNAs have been performed in model plants such as rice, Arabidopsis thaliana and other plants. However, the number of mi...
ORGANISM(S): Zea mays 
2014-10-22 | E-GEOD-47837 | biostudies-arrayexpress
TranscriptomicsTranscript abundance comparison between BALB/c ears inoculated with Leishmania mexicana and Leishmania mexicana plus promastigote secretory gel (PSG)
To determine the modulation of gene expression of Leishmania mexicana(M379)-inoculated BALB/c ears in the presence of promastigote secretory gel (PSG) A genome-wide transcriptional analysis was performed by comparing the gene expression profiles of Leishmania mexicana- inoculated BALB/c ears and L...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-52101 | biostudies-arrayexpress
UnknownAminoacyl-tRNA synthetase deficiencies in search of common themes.
Not available
S-EPMC7091658 | biostudies-literature
TranscriptomicsVariant-specific interaction of kinectin 1 with the multi–tRNA synthetase complex regulates ER sheet organization
Kinectin 1 (KTN1) is an integral endoplasmic reticulum (ER) sheet protein that functions in ER organization and translation elongation. Alternative splicing introduces sequence diversity into the cytoplasmic region of KTN1, but the functional relevance of these variants has remained unclear. Here we...
ORGANISM(S): Homo sapiens 
2025-11-01 | GSE308892 | GEO
UnknownVariant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organization.
Not available
S-EPMC12768868 | biostudies-literature
TranscriptomicsGenome-wide Measurement of RNA Secondary Structure in Yeast
The structures of RNA molecules are often important for their function and regulation, yet there are no experimental techniques for genome-scale measurement of RNA structure. Here, we describe a novel strategy termed Parallel Analysis of RNA Structure (PARS), which is based on deep sequencing fragme...
ORGANISM(S): Saccharomyces cerevisiae 
2010-08-24 | E-GEOD-22393 | biostudies-arrayexpress
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