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GenomicsChIP-seq Identification of Weakly Conserved Heart Enhancers
Accurate control of tissue-specific gene expression plays a pivotal role in heart development. However, few cardiac transcriptional enhancers have thus far been identified. Extreme non-coding sequence conservation successfully predicts enhancers active in many tissues, but fails to identify substan...
ORGANISM(S): Mus musculus 
2010-08-22 | E-GEOD-22549 | biostudies-arrayexpress
GenomicsLarge-Scale Discovery of Enhancers from Human Heart Tissue
Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers. While large numbers of heart enhancers have been identified using the mouse as a model system, many of these regulatory sequences are poorly cons...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-32587 | biostudies-arrayexpress
GenomicsChIP-seq Accurately Predicts Tissue-Specific Activity of Enhancers
Determining the spatial and temporal activity patterns of enhancers remains a challenge in the functional annotation of the human genome. Here, we performed genome-wide mapping of tissue-specific in vivo binding sites for the enhancer-associated protein p300 and assessed in transgenic mice the util...
ORGANISM(S): Mus musculus 
2009-02-11 | E-GEOD-13845 | biostudies-arrayexpress
UnknownGWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Not available
S-EPMC10208981 | biostudies-literature
UnknownA second update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC10482689 | biostudies-literature
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