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GenomicsGenome wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved at least partly through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 1...
ORGANISM(S): Mus musculus 
2009-05-20 | E-GEOD-15896 | biostudies-arrayexpress
ProteomicsElucidation of BMI1, RYBP and H2AK119ub interactomes in Glioblastoma
Identification of BMI1, RYBP and H2AK119UB interactome in Glioblastoma (GBM) to elucidate BMI1 roles independent of the PRC1-complex in GBM.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022057 | Pride
H2ak119ub Bmi1 Proteomics Glioblastoma Ipms Chipms Rybp Gbm Lc-ms/ms 
TranscriptomicsTranscriptomic analysis of Bmi1 overexpression in NSPC.
We have previously shown that conditional overexpression of Bmi1 in NSC increases their proliferation both in the developing neocortexand in the postnatal brain (Yadirgi et al. 2011). However, during embryonic development, increased and ectopic proliferation induced by overexpression of Bmi1 in prog...
ORGANISM(S): Mus musculus 
2012-11-12 | E-GEOD-31607 | biostudies-arrayexpress
TranscriptomicsExpression data from Bmi1-null c-Kit+Sca-1+Lineage marker- (KSL) hematopoietic stem/progenitor cells
Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dep...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-19796 | biostudies-arrayexpress
TranscriptomicsMurine Proerythroblasts (ProEs): WT vs. Bmi1-/-
Transcriptional profiling of ProEs purified from wild type and Bmi1-/- mice. Two-condition experiment, WT vs. Bmi1-/- ProEs. Biological replicates: 3 WT replicates, 3 Bmi1-/- replicates.
ORGANISM(S): Mus musculus 
2014-11-18 | E-GEOD-63413 | biostudies-arrayexpress
TranscriptomicsMurine Myeloid-Erythroid Progenitors (MEPs): WT vs. Bmi1-/-
Transcriptional profiling of MEPs purified from wild type and Bmi1-/- mice. Two-condition experiment, WT vs. Bmi1-/- MEPs. Biological replicates: 3 WT replicates, 3 Bmi1-/- replicates.
ORGANISM(S): Mus musculus 
2014-11-18 | E-GEOD-63411 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Bmi1-overexpressing Ink4a-Arf-null hepatoblasts
Forced expression of Bmi1 accelerated the self-renewal of hepatic stem/progenitor cells and eventually induced their transformation in an in vivo transplant model. The Ink4a/Arf locus, which encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf, is a pivotal target of...
ORGANISM(S): Mus musculus 
2009-08-07 | E-GEOD-17462 | biostudies-arrayexpress
TranscriptomicsRNA-seq in wild type and Bmi1 knockdown undifferentiated spermatogonia
Mammalian spermatogenesis is regulated by epigenetic mechanisms that maintain cell type-specific transcriptional programs. The epigenetic regulator BMI1, a PRC1 member, is required for maintaining undifferentiated spermatogonia, but the underlying mechanisms remain unclear. To address this issue, he...
ORGANISM(S): Mus musculus 
2023-12-30 | E-MTAB-11777 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of BMI1-silenced human prostate cancer cells
BMI1-silenced Prostate cancer cells exhibited a significant change in the expression of several proliferation-associated genes. These included Cyclin-D1, BCL2, IL and NF-kappaB. An increased expression of p16, p15 and TIMP3 in BMI1-silenced tumor cells was observed List of Selected Genes Modulated b...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-44049 | biostudies-arrayexpress
TranscriptomicsBMI1 regulates myogenic differentiation, Hippo signaling, and oncogene expression in embryonal rhabdomyosarcoma.
The purpose of our study was to examine the function of BMI1 in fusion positive and fusion negative rhabdomyosarcoma cell lines and validate these findings in patient tissue. RD and RH30 cell lines were treated with control-siRNA or BMI1-siRNA and the RNA was subsequently sequenced on a HiSeq2500. ...
ORGANISM(S): Homo sapiens 
2016-12-20 | E-MTAB-4237 | biostudies-arrayexpress
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