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TranscriptomicsTranscription profiling of human normal subjects and IPAH patients to examine the effect of BMP-2 on pulmonary artery smooth muscle cells
Bone morphogenetic proteins (BMP) inhibit proliferation and induce apoptosis in pulmonary artery smooth muscle cells (PASMC) from normal subjects. Dysfunction of BMP signaling due to mutations in and/or downregulation of BMP receptors has been implicated in idiopathic pulmonary arterial hypertension...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2559 | biostudies-arrayexpress
TranscriptomicsExpression data of human pulmonary arterial smooth muscle cells (PASMCs) treated with BMP-4
Smad1/5 are transcription factors that engage in BMP-induced transcription. We determined and analyzed Smad1/5 binding sites by ChIP-sequencing. We used expression microarrays to compare the Smad1/5 binding sites identified by ChIP-seq to BMP-induced gene expressions. PASMCs were treated with 50 ng/...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-28847 | biostudies-arrayexpress
TranscriptomicsExpression data of human umbilical vein endothelial cells (HUVECs) treated with BMP-6 and BMP-9
Smad1/5 are transcription factors that engage in BMP-induced transcription. We determined and analyzed Smad1/5 binding sites by ChIP-sequencing. We used expression microarrays to compare the Smad1/5 binding sites identified by ChIP-seq to BMP-induced gene expressions. HUVECs were treated with BMP fo...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-27631 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse C3H10T1/2 stem cells committed to the adipocyte lineage by treatment with BMP-4
C3H10T1/2 stem cells are committed to the adipocyte lineage by treatment with BMP-4 and grown to postconfluence. When subjected to our standard differentiation protocol, the committed cells differentiate into adipocytes in a manner indistinguishable from that of 3T3-L1 preadipocytes. In contrast, ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5921 | biostudies-arrayexpress
ProteomicsBeta cell dysfunction and dedifferentiation induced by Bone Morphogenetic Protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding
Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by a decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Langerhans from diabetic individuals and acts as an...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD036655 | Pride
Rna Histone Bmp-2 Proteomics 
GenomicsSMAD1/5 binding regions of human umbilical vein endothelial cells (HUVECs) treated with BMP.
Smad1/5 binding regions were identified by ChIP-seq. HUVECs were treated with BMP for 1.5 h and anti-SMAD1/5 ChIP-seq analyses were performed using Illumina genome analyzer.
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-27634 | biostudies-arrayexpress
TranscriptomicsBMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
The transition from progenitor to differentiated cells is critical for successful organogenesis; subtle alterations in this process can lead to developmental disorders. The anterior heart field (AHF) encompasses a niche in which cardiac progenitors maintain their multipotent and undifferentiated nat...
ORGANISM(S): Gallus gallus 
2010-08-01 | E-GEOD-19698 | biostudies-arrayexpress
GenomicsATAC-seq of BMP response in glioblastoma-derived neural stem cells
Chromatin accessibility was profiled by ATAC-seq in normal and glioblastoma-derived neural stem (GNS) cells, in self-renewing conditions and in response to differentiation stimulus with bone morphogenic protein (BMP).
ORGANISM(S): Homo sapiens 
2015-10-01 | E-MTAB-3868 | biostudies-arrayexpress
TranscriptomicsEffect of BMP4 and noggin on gene expression in murine R1 ES cells
To confirm that the SMAD1/5- and SMAD4-associated genes are direct transcriptional regulators in mESCs in response to BMP, we treated undifferentiated R1 ES cells with BMP4 or with the BMP4 antagonist noggin, which can inhibit BMP signaling effectively for 4 h. Undifferentiated R1 ES cells were trea...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-20527 | biostudies-arrayexpress
TranscriptomicsA Xenopus DNA microarray approach to identify novel direct BMP target genes involved in early embryonic development
Bone Morphogenetic Proteins (BMPs), a subgroup of the TGF- superfamily, were originally isolated from bone on the basis of their ability to induce ectopic bone development. While BMPs are involved in a wide range of developmental and physiological functions, very few vertebrate target genes in t...
ORGANISM(S): Xenopus laevis 
2010-06-10 | E-GEOD-2274 | biostudies-arrayexpress
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