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TranscriptomicsTranscription profiling of human normal subjects and IPAH patients to examine the effect of BMP-2 on pulmonary artery smooth muscle cells
Bone morphogenetic proteins (BMP) inhibit proliferation and induce apoptosis in pulmonary artery smooth muscle cells (PASMC) from normal subjects. Dysfunction of BMP signaling due to mutations in and/or downregulation of BMP receptors has been implicated in idiopathic pulmonary arterial hypertension...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2559 | biostudies-arrayexpress
ProteomicsBeta cell dysfunction and dedifferentiation induced by Bone Morphogenetic Protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding
Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by a decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Langerhans from diabetic individuals and acts as an...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD036655 | Pride
Rna Histone Bmp-2 Proteomics 
TranscriptomicsGenome-wide analysis of endocytosis inhibition on BMP-2 induced gene expression in C2C12 cells
Analysis of BMP-2 induced gene expression of C2C12 cells treated with the endocytosis inhibitor dynasore to identify gene expression profiles which are sensitive to endocytosis inhibition. Our data highlight the importance of endocytosis for transmission of an extracellular BMP-2 signal into the nuc...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-29373 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse C3H10T1/2 stem cells committed to the adipocyte lineage by treatment with BMP-4
C3H10T1/2 stem cells are committed to the adipocyte lineage by treatment with BMP-4 and grown to postconfluence. When subjected to our standard differentiation protocol, the committed cells differentiate into adipocytes in a manner indistinguishable from that of 3T3-L1 preadipocytes. In contrast, ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5921 | biostudies-arrayexpress
GenomicsGene expression profiling in salivary glands by BMP-2.
Gene expression profiling in salivary glands by BMP-2.
PRJNA1003831 | ENA
TranscriptomicsExpression data of human pulmonary arterial smooth muscle cells (PASMCs) treated with BMP-4
Smad1/5 are transcription factors that engage in BMP-induced transcription. We determined and analyzed Smad1/5 binding sites by ChIP-sequencing. We used expression microarrays to compare the Smad1/5 binding sites identified by ChIP-seq to BMP-induced gene expressions. PASMCs were treated with 50 ng/...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-28847 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MSC isolated from human bone marrow aspirates differentiated to chondrocytes with BMP2 or TGFbeta-3, vs undifferentiated MSC sampled at multiple time points
Human mesenchymal stem cells (MSC) display a high potential for the development of novel treatment strategies for cartilage repair. However, the pathways involved in their differentiation to functional and non hypertrophic chondrocytes remain largely unknown, despite the work on embryologic developm...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10315 | biostudies-arrayexpress
TranscriptomicsBMP-2-responsive genes in mouse periodontal ligament-derived PDL-L2 cells with and without endoglin knockdown
This study was designed to identify endoglin (ENG)-dependent BMP2-responsive genes in the mouse fibroblastic cell line PDL-L2. PDL-L2 cells were treated with an siRNA for endoglin (siENG) or a control siRNA (siCont). After 48hr, the cells were exposed to recombinant human BMP-2 (250 ng/ml) or vehicl...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-54220 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of sympathetic neurons during BMP-induced primary dendritogenesis
The objective of this study was to identify genes that are differentially regulated in cultured sympathetic neurons during BMP-induced dendritic growth and to determine the temporal expression patterns of these genes. We determined that inhibiting transcription within the first 24 hours after adding...
ORGANISM(S): Rattus norvegicus 
2011-06-30 | E-GEOD-28150 | biostudies-arrayexpress
TranscriptomicsEffects of RGMc on BMP2 and BMP6-mediated Gene Expression in Hep3B Liver Cells
Mutations in repulsive guidance molecule c (RGMc) / hemojuvelin (HJV) cause juvenile hemochromatosis, an aggravated iron overload disorder that presents early in life. Patients with juvenile hemochromatosis, and RGMc knockout mice, have diminished expression of the key iron-regulatory peptide, hepc...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-20671 | biostudies-arrayexpress
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