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ProteomicsAn Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity
Cancer cells are often aneuploid and frequently display elevated rates of chromosome mis-segregation, called chromosomal instability (CIN). CIN is caused by hyperstable kinetochore-microtubule (K-MT) attachments that reduce the correction efficiency of erroneous K-MT attachments. UMK57, a chemical a...
ORGANISM(S): Homo sapiens (Human) 
2025-02-18 | PXD058824 | Pride
Kinase Phosphatase Pp2a Kinetochore Aurora a Bod1l1 
UnknownAn Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity.
Not available
S-EPMC10441337 | biostudies-literature
UnknownAn Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity.
Not available
S-EPMC11962599 | biostudies-literature
Proteomics¬An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity
The goal of this experiment was to discover mediators of resistance to the MCAK agonist chemical UMK57. Naive SW620 cells were compared to cells exposed to UMK57 for 3 days, and then all cells were synchronized in mitosis. The cells were then harvested, frozen and sent for phosphoproteomic analysis....
ORGANISM(S): Homo sapiens (Human) 
2025-02-18 | PXD058823 | Pride
Aurora kinase Kinase Phosphoproteome Phosphatase 
Proteomics¬An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity
The objective of this experiment is to discover mediators of resistance to the MCAK agonist compound UMK57. In this experiment, SW620 cells treated with DMSO were compared to SW620 cells exposed to UMK57 for 3 days prior to mitotic synchronization and harvesting. The samples were then processed and ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-18 | PXD058821 | Pride
Kinase Phosphatase Kinetochore Aurora a 
UnknownIdentification of Gene Coexpression Modules and Prognostic Genes Associated with Papillary Thyroid Cancer.
Not available
S-EPMC9553521 | biostudies-literature
UnknownWhole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma.
Not available
S-EPMC9712679 | biostudies-literature
UnknownCausal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency.
Not available
S-EPMC9006976 | biostudies-literature
UnknownA Polygenic Risk Score for Late Bladder Toxicity Following Radiotherapy for Non-Metastatic Prostate Cancer.
Not available
S-EPMC12048210 | biostudies-literature
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