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ProteomicsActivation of FAM111A Protease Induces Defects in Nuclear Function that Likely Underlie its Roles in Disease and Viral Restriction
Mutations in the nuclear trypsin-like serine protease FAM111A cause Kenny-Caffey syndrome (KCS2) with hypoparathyroidism and skeletal dysplasia, or perinatally lethal osteocraniostenosis (OCS). In addition, FAM111A was identified as a restriction factor for certain host range mutants of the SV40 pol...
ORGANISM(S): Homo sapiens (Human) 
2020-11-25 | PXD020327 | Pride
Fam111a Sv40polyomavirus Kcs2 Vacv Mass spectrometry Ocs 
ProteomicsThe Human Nse5 Orthologue SIMC1 Localizes SMC5/6 to Polyomavirus Replication Centers
The human SMC5-SMC6 complex (SMC5/6) is a conserved guardian of genome stability and an emerging component of the antiviral response in animals and plants. In yeast, Smc5/6 is recruited to and loaded on chromatin by the poorly conserved Nse5-Nse6 heterodimer (Nse5/6), which remains largely undefined...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033923 | Pride
Nse5 Lcms Simc1 localizes smc5/6 
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