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ProteomicsThe Human Nse5 Orthologue SIMC1 Localizes SMC5/6 to Polyomavirus Replication Centers
The human SMC5-SMC6 complex (SMC5/6) is a conserved guardian of genome stability and an emerging component of the antiviral response in animals and plants. In yeast, Smc5/6 is recruited to and loaded on chromatin by the poorly conserved Nse5-Nse6 heterodimer (Nse5/6), which remains largely undefined...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033923 | Pride
Nse5 Lcms Simc1 localizes smc5/6 
ProteomicsNse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding
Eukaryotic cells employ three SMC complexes to control DNA folding and topology. The Smc5/6 complex plays roles in DNA repair and in preventing the accumulation of deleterious DNA junctions. To elucidate how specific features of Smc5/6 govern these functions, we reconstituted the yeast holo-complex....
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-02 | PXD024160 | Pride
Atpase Condensin Loop extrusion Chromosome segregation Xl-ms Smc5 Smc Smc6 Genome maintenance Cohesin 
UnknownNse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
Not available
S-EPMC8327961 | biostudies-literature
UnknownThe Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.
Not available
S-EPMC9708086 | biostudies-literature
UnknownMolecular basis for Nse5-6 mediated regulation of Smc5/6 functions.
Not available
S-EPMC10636319 | biostudies-literature
GenomicsSNI1/NSE5 is a cold-sensitive brake on Class II crossovers
SNI1/NSE5 is a cold-sensitive brake on Class II crossovers
PRJEB102775 | ENA
UnknownNse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
Not available
S-EPMC8096239 | biostudies-literature
UnknownNse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding
Not available
S-SCDT-EMBOJ-2021-107807P | biostudies-other
UnknownA point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).
Not available
S-EPMC3841196 | biostudies-literature
UnknownThe Smc5/6 complex is a DNA loop-extruding motor.
Not available
S-EPMC10132971 | biostudies-literature
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