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TranscriptomicsDiversity in the polyadenylation and decay of human cellular microRNAs during Vaccinia virus infection
Vaccinia virus (VACV) is a large cytoplasmic dsDNA virus that causes dramatic alterations to many cellular pathways including microRNA biogenesis. Here we use small RNA sequencing to comprehensively quantify the impact of VACV infection on the expression of endogenous small non-coding RNAs (sncRNAs)...
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-54235 | biostudies-arrayexpress
ProteomicsComparison of the Cowpox Virus and Vaccinia Virus Mature Virion Proteome: Analysis of the species- and strain-specific Proteome
Cowpox virus (CPXV) causes most zoonotic orthopoxvirus (OPV) infections in Europe and Northern as well as Central Asia. The virus has the broadest host range of OPV and is transmitted to humans from rodents and other wild or domestic animals. Increasing numbers of human CPXV infections in a populati...
ORGANISM(S): Orthopoxvirus 
2015-11-16 | PXD003013 | Pride
Ltq-orbitrap Virion proteome Orthopoxvirus 
ProteomicsSelective modulation of cell surface proteins during vaccinia infection: a resource for identifying viral immune evasion strategies
The interaction between immune cells and virus-infected targets involves multiple plasma membrane (PM) proteins. A systematic study of PM protein modulation by vaccinia virus (VACV), the paradigm of host regulation, has the potential to reveal not only novel viral immune evasion mechanisms, but also...
ORGANISM(S): Homo sapiens (Human) Vaccinia virus WR Vaccinia virus 
2022-06-01 | PXD033407 | Pride
Vaccinia virus  plasma membrane  immune evasion  host-pathogen interaction 
TranscriptomicsmRNA expression profiles of antigen-specific CD8+ T cells induced by DNA prime-DNA boost and DNA prime-VACV boost immunization regimen
Similar with others, our data proved that antigen-specific CD8+ T cells from mice primed with DNA and boosted by VACV were much more sensitive to antigen stimulation than those from DNA-boost. Since the mechanisms of in vivo tuning of antigen sensitivity (also termed functional avidity) is still not...
ORGANISM(S): Mus musculus 
2013-10-30 | GSE51849 | GEO
Genomics
Coding-complete sequencing of VACV Copenhagen strains
PRJNA902654 | ENA
TranscriptomicsmRNA expression profiles of antigen-specific CD8+ T cells induced by DNA prime-DNA boost and DNA prime-VACV boost immunization regimen
Similar with others, our data proved that antigen-specific CD8+ T cells from mice primed with DNA and boosted by VACV were much more sensitive to antigen stimulation than those from DNA-boost. Since the mechanisms of in vivo tuning of antigen sensitivity (also termed functional avidity) is still not...
ORGANISM(S): Mus musculus 
2013-10-30 | E-GEOD-51849 | biostudies-arrayexpress
UnknownOne more piece in the VACV ecological puzzle: could peridomestic rodents be the link between wildlife and bovine vaccinia outbreaks in Brazil?
Not available
S-EPMC2758550 | biostudies-literature
ProteomicsB27 inmunopeptidome in vaccinica infected cells
Identification of natural human leukocyte antigen (HLA) ligandome is a key element to understand the cellular immune responses. Advanced high throughput mass spectrometry analyses identify a relevant, but not complete, fraction of the many tens of thousands of self-peptides generated by the antigen ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-22 | PXD027859 | Pride
Hla-b*27 Vaccinica Hla Immunopeptidomics 
UnknownSerological differentiation between naturally acquired mpox and MVA-BN-vaccine induced antibody responses using ratios of MPXV and VACV antigen pairs in the MSD immunoassay.
Not available
S-EPMC12403559 | biostudies-literature
UnknownSingle-cell analysis of VACV infection reveals pathogen-driven timing of early and late phases and host-limited dynamics of virus production.
Not available
S-EPMC11347022 | biostudies-literature
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