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ProteomicsUSP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature CMG unloading and replisome disassembly are poorly described. Since...
ORGANISM(S): Homo sapiens (Human) 
2025-05-16 | PXD061463 | Pride
Usp37 Cell cycle Ubiquitin Dna replication Replisome 
ProteomicsHepatocyte thorns, a novel drug-induced stress response in human and mouse liver spheroids
The in vivo-relevant phenotype of 3D liver spheroids allows for long-term studies of e.g. novel mechanisms of chronic drug-induced liver toxicity. Using this system, we present a novel drug-induced stress response in human and murine hepatocyte spheroids wherein long slender filaments form after chr...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD033550 | Pride
Hepatocytes  spheroids  thorns  hepatotoxicity  keratins  3d culture 
UnknownA structure-based designed small molecule depletes hRpn13<sup>Pru</sup> and a select group of KEN box proteins.
Not available
S-EPMC10954691 | biostudies-literature
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