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ProteomicsUSP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature CMG unloading and replisome disassembly are poorly described. Since...
ORGANISM(S): Homo sapiens (Human) 
2025-05-16 | PXD061463 | Pride
Usp37 Cell cycle Ubiquitin Dna replication Replisome 
GenomicsUSP37 Promotes Deubiquitination of HIF2a in Kidney Cancer
USP37 Promotes Deubiquitination of HIF2a in Kidney Cancer
PRJNA627118 | ENA
ProteomicsUSP37 protects mammalian cells during DNA replication stress by counteracting CUL2-LRR1 and TRAIP
We have found that the USP37 deubiquitylase binds to the DNA helicase known as CMG (Cdc45-Mcm-GINS) in mammalian cells. CMG unwinds the parental DNA duplex during the process of chromosome duplication, and USP37 is important to help cells survive problems in DNA replication.In this project, we inve...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-09 | PXD056491 | Pride
Usp37 Atr checkpoint kinase Ubiquitylation Deubiquitylase Traip Cmg helicase Cul2-lrr1 Dna replication 
TranscriptomicsUSP37 Promotes Deubiquitination of HIF2a in Kidney Cancer
Clear cell renal cell carcinoma (ccRCC) is characterized by a loss of tumor suppressor Von Hippel Lindau (VHL) function, which leads to accumulation of hypoxia inducible factor (including HIF1 and HIF2). HIF2 was previously reported to be one of the major oncogenic drivers in ccRCC, however its ther...
ORGANISM(S): Homo sapiens 
2020-05-27 | GSE149005 | GEO
UnknownUSP37 promotes deubiquitination of HIF2α in kidney cancer.
Not available
S-EPMC7293621 | biostudies-literature
UnknownUSP37 prevents unscheduled replisome unloading through MCM complex deubiquitination.
Not available
S-EPMC11398414 | biostudies-literature
UnknownUSP37 prevents unscheduled replisome unloading through MCM complex deubiquitination.
Not available
S-EPMC12084625 | biostudies-literature
UnknownUSP37 deubiquitinates Cdt1 and contributes to regulate DNA replication.
Not available
S-EPMC5423201 | biostudies-literature
UnknownUSP37 prevents premature disassembly of stressed replisomes by TRAIP.
Not available
S-EPMC11398331 | biostudies-literature
UnknownUSP37 prevents premature disassembly of stressed replisomes by TRAIP.
Not available
S-EPMC12177040 | biostudies-literature
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