Replisome - OmicsDI

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Fork Pausing Complex Engages Topoisomerases at the Replisome

PRJNA588062 | ENA

Conflict resolution between the replisome and Pol II

PRJNA1266634 | ENA

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature CMG unloading and replisome disassembly are poorly described. Since...

ORGANISM(S): Homo sapiens (Human)

2025-05-16 | PXD061463 | Pride

Fork Pausing Complex Engages Topoisomerases at the Replisome

Replication forks temporarily or terminally pause at hundreds of hard-to-replicate regions around the genome. A conserved pair of budding yeast replisome components Tof1-Csm3 (fission yeast Swi1-Swi3 and human TIMELESS-TIPIN) acts as a ‘molecular brake’ and promotes fork slowdown at proteinaceous re...

ORGANISM(S): Saccharomyces cerevisiae

2019-11-07 | GSE140034 | GEO

Conflict resolution between the replisome and Pol II [RNA-seq]

PRJNA1267169 | ENA

Conflict resolution between the replisome and Pol II [bTMP-seq]

PRJNA1266635 | ENA

Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading

Rescuing the bacterial replisome at a nick: sequencing data

PRJEB102268 | ENA

LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components.

Not available

S-EPMC8160578 | biostudies-literature