Sort   by:  
 Page size 
ProteomicsRadioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis
Antifibrotic therapy with nintedanib is the clinical mainstay in the treatment of progressive fibrosing interstitial lung disease (ILD). High-dimensional medical image analysis, known as radiomics, provides quantitative insights into organ-scale pathophysiology, generating digital disease fingerprin...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052594 | Pride
Interstitial lung disease Radiomics Proteomics Multiomics Imaging Lung fibrosis Nintedanib 
TranscriptomicsGenome-wide Analysis of Transcriptional Reprogramming in Mouse Models of Acute Myeloid Leukaemia
Acute leukaemias are commonly caused by mutations that corrupt the transcriptional circuitry of haematopoietic stem/progenitor cells. However, the mechanisms underlying large-scale transcriptional reprogramming remain largely unknown. Here we investigated transcriptional reprogramming at genome-scal...
ORGANISM(S): Mus musculus 
2011-02-17 | E-GEOD-25539 | biostudies-arrayexpress
ProteomicsInference of Kinase-Signaling Networks in Human Myeloid Cell Line Models by Phosphoproteomics using Kinase Activity Enrichment Analysis (KAEA)
Despite the indisputable efficacy of kinase-inhibitors in myeloid malignancies, cure remains an exception and most patients eventually progress. Therefore, there is an unmet clinical need in developing diagnostic pipelines for the characterization of kinase-activities and signaling networks to inves...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024806 | Pride
Phosphoproteomics Kinase-signaling network Myeloid malignancies Kinase activity 
GenomicsThe Transcriptional Programme Controlled by Scl/Tal1 Gene during Early Embryonic Haematopoietic Development
The basic-helix-loop-helix transcription factor Scl/Tal1 controls the development and subsequent differentiation of haematopoietic stem cells (HSCs). However, since few Scl target genes have been validated to date, the underlying mechanisms have remained largely unknown. Here we have employed ChIP...
ORGANISM(S): Mus musculus 
2009-06-19 | E-GEOD-15806 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse hematopoietic cell lines and tissue-types to identify histone modification and transcription factor binding sites
Histone modification and transcription factor ChIP-chip in hematopoietic cell lines and tissue-types
ORGANISM(S): Mus musculus 
2009-01-28 | E-TABM-431 | biostudies-arrayexpress
Sort   by:  
 Page size