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UnknownMapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach.
Not available
S-EPMC6870988 | biostudies-literature
ProteomicsPooled scanning of protein variants identifies novel RNA-binding mutants
Binding to RNA has been observed for an ever-increasing number of proteins, which often have other functions. The contributions of RNA binding to protein function are best discerned by studying “separation-of-function” mutants that hamper interaction with RNA without affecting other aspects of prote...
ORGANISM(S): Escherichia coli 
2025-06-20 | PXD062465 | Pride
Lc-ms Protein-rna interactions Technology development Rna-binding proteins Peptide barcodes 
ProteomicsMapping RNA interactions of human ATRX with RepA fragment of Xist
Heterochromatin in the eukaryotic genome is rigorously controlled by the concerted action of protein factors and RNAs. Here, we investigate the RNA binding function of ATRX, a chromatin remodeler with roles in silencing of repetitive regions of the genome and in recruitment of the polycomb repressi...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD017806 | Pride
Rbrid  rna-protein interactions  rna-binding 
TranscriptomicsThe C-Terminal Domain of RNA Polymerase II is Modified by Site-Specific Methylation
The Carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) in mammals undergoes extensive post-translational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the transcriptional co-...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-27315 | biostudies-arrayexpress
TranscriptomicsRNA seq in two lines of E14 mouse embryonic stem cells
This experiment was designed to obtain the polyA+ transcriptome in E14 ESCs PolyA+ RNA was extracted and purified from two separate clones of E14, which were treated as biological replicate
ORGANISM(S): Mus musculus 
2013-10-19 | E-GEOD-49434 | biostudies-arrayexpress
TranscriptomicsIn vivo proximity labeling and sequencing (IPL-seq) for SNRPN70 in 293T-Rex
This proof-of-principle experiment was designed to demonstrate the feasibility of proximity labeling for RNAM-bM-^@M-^Sprotein interactions IPL-seq on 293T-Rex expressing MSA-SNRPN70 (sample) or NFH-SNRPN70 (control)
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-55370 | biostudies-arrayexpress
GenomicsSIRT3 functions in the nucleus in the control of stress-related gene expression.
SIRT3 is a member of the Sir2 family of NAD+-dependent protein deacetylases that promotes longevity in many organisms. The processed, short form of SIRT3 is a well-established mitochondrial protein whose deacetylase activity regulates various metabolic processes. However, the presence of full-length...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41000 | biostudies-arrayexpress
GenomicsChIP-seq for PRC2 components and H3K27me3 in E14 mouse embryonic stem cells
This experiment sought to determine the chromatin structure and PRC2 occupancy at the promoters of all genes in mouse ESCs ChIP-seq for EZH2, SUZ12, and H3K27me3 were performed on WT E14 cells in 2 biological replicates each. In addition H3K27me3 ChIP-seq was also performed on a clone of E14 cells e...
ORGANISM(S): Mus musculus 
2013-10-19 | E-GEOD-49431 | biostudies-arrayexpress
UnknownDistinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
Not available
S-EPMC8217195 | biostudies-literature
UnknownTET2 chemically modifies tRNAs and regulates tRNA fragment levels.
Not available
S-EPMC7855721 | biostudies-literature
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